| Sylvester Stallone | .... | Rocky Balboa |
| Burt Young | .... | Paulie |
| Antonio Tarver | .... | Mason 'The Line' Dixon |
| Geraldine Hughes | .... | Marie |
| Milo Ventimiglia | .... | Robert Balboa Jr. |
| Tony Burton | .... | Duke |
| A. J. Benza | .... | L.C. |
| James Francis Kelly III | .... | Steps |
| Talia Shire | .... | Adrian(archive footage) |
| Lou DiBella | .... | Lou DiBella |
| Mike Tyson | .... | Mike Tyson |
| Henry G. Sanders | .... | Martin |
| Pedro Lovell | .... | Spider Rico |
| Ana Gerena | .... | Isabel |
| Angela Boyd | .... | Angie |
| Louis Giansante | .... | Bar Thug |
| Maureen Schilling | .... | Lucky's Bartender |
| Lahmard Tate | .... | X-Cell |
| Woodrow W. Paige | .... | ESPN Commentator |
| Skip Bayless | .... | ESPN Commentator |
| Jay Crawford | .... | ESPN Commentator |
| Brian Kenny | .... | ESPN Host |
| Dana Jacobson | .... | ESPN Host |
| Chuck Johnson | .... | ESPN Host |
| James J. Binns | .... | Commissioner |
| Johnnie Hobbs Jr. | .... | Commissioner |
| Barney Fitzpatrick | .... | Commissioner |
| Jim Lampley | .... | HBO Commentator |
| Larry Merchant | .... | HBO Commentator |
| Max Kellerman | .... | HBO Commentator |
| LeRoy Neiman | .... | LeRoy Neiman |
| Bert Randolph Sugar | .... | Ring Magazine Reporter |
| Bernard Fernandez | .... | Boxing Association of America Writer |
| Gunnar Peterson | .... | Weightlifting Trainer |
| Yahya | .... | Dixon's Opponent |
| Marc Ratner | .... | Weigh-In Official |
| Anthony Lato Jr. | .... | Rocky's Inspector |
| Jack Lazzarado | .... | Dixon's Inspector |
| Michael Buffer | .... | Ring Announcer |
| Joe Cortez | .... | Referee |
| Carter Mitchell | .... | Shamrock Foreman |
| Vinod Kumar | .... | Ravi |
| Fran Pultro | .... | Father at Restaurant |
| Frank Stallone Jr. | .... | Dinner Patron |
| Jody Giambelluca | .... | Dinner Patron |
| Tobias Segal | .... | Robert's Friend |
| Tim Carr | .... | Robert's Friend |
| Matt Frack | .... | Robert's Friend #3 |
| Paul Dion Monte | .... | Robert's Friend |
| Kevin King-Templeton | .... | Robert's Friend |
| Robert Michael Kelly | .... | Mr. Tomilson |
| Rick Buchborn | .... | Rocky Fan |
| Nick Baker | .... | Irish Pub Bartender |
| Don Sherman | .... | Andy |
| Stu Nahan | .... | Computer Fight Commentator (voice) |
| Gary Compton | .... | Security Guard |
| Vale Anoai | .... | Shopper in Italian Market |
| Sikander Malik | .... | Boxer |
| Michael Ahl | .... | Restaurant Patron (uncredited) |
| Andrew Aninsman | .... | Promoter (uncredited) |
| Ben Bachelder | .... | The Arm (uncredited) |
| Lacy Bevis | .... | Boxing Spectator (uncredited) |
| Tim Brooks | .... | Boxing Spectator (uncredited) |
| D. T. Carney | .... | High Roller (uncredited) |
| Ricky Cavazos | .... | Boxing Spectator (uncredited) |
| Rennie Cowan | .... | Boxing Spectator (uncredited) |
| Kevin Deon | .... | Jeno (uncredited) |
| Jacob 'Stitch' Duran | .... | Dixon's Trainer (uncredited) |
| Amy Seddon Ebert | .... | Promoter's Wife (uncredited) |
| Simon Edwards | .... | Crowd Member (uncredited) |
| Mark Falvo | .... | Adrian's Patron (uncredited) |
| Ruben Fischman | .... | High-Roller in Las Vegas (uncredited) |
| Renee Fishman | .... | Mother of Picture Kid at Adrian's Restaurant (uncredited) |
| David Gere | .... | Patron at Adrian's (uncredited) |
| Noah Jacobs | .... | Boxing Fan (uncredited) |
| Basil Kershner | .... | Restaurant Patron (uncredited) |
| Mark J. Kilbane | .... | Businessman (uncredited) |
| Zach Klinefelter | .... | Boxing Spectator (uncredited) |
| David Collihan | .... | Adrian's Patron (uncredited) |
| Lenny Lenox | .... | Boxing Spectator (uncredited) |
| Dolph Lundgren | .... | Captain Ivan Drago(archive footage) (uncredited) |
| Burgess Meredith | .... | Mickey Goldmill(archive footage) (uncredited) |
| Robert L. Mickles | .... | Irish Pub Patron (uncredited) |
| Dan Montero | .... | Boxing Spectator (uncredited) |
| Babs Moran | .... | Obnoxious Fan (uncredited) |
| Keith Moyer | .... | Bar Patron (uncredited) |
| Mr. T | .... | Clubber Lang(archive footage) (uncredited) |
| Carol Anne Mueller | .... | Restaurant Patron (uncredited) |
| Keyvan Neal | .... | Boxing Fan (uncredited) |
| Jacqueline Olivia | .... | Girl (uncredited) |
| Robert Patriarca | .... | Rocky Fan (uncredited) |
| Charlie Pham | .... | Street Merchant (uncredited) |
| Ricky Roma | .... | Boxing fan (uncredited) |
| Fulvia Santoni | .... | Ring Girl (uncredited) |
| Brian H. Scott | .... | Ringside Cop #1 (uncredited) |
| Keyon Smith | .... | Boxing Spectator (uncredited) |
| Frank Traynor | .... | Lawyer (uncredited) |
| Ryan Tygh | .... | Ring Photographer (uncredited) |
| Greg Van Cott | .... | Teen boxing fan (uncredited) |
| Kimberly Villanova | .... | Businesswoman (uncredited) |