 | Ed Helms | .... | Rusty Griswold |
 | Christina Applegate | .... | Debbie Griswold |
 | Skyler Gisondo | .... | James Griswold |
 | Steele Stebbins | .... | Kevin Griswold |
 | Chris Hemsworth | .... | Stone Crandall |
 | Leslie Mann | .... | Audrey Crandall |
 | Chevy Chase | .... | Clark Griswold |
 | Beverly D'Angelo | .... | Ellen Griswold |
 | Charlie Day | .... | Chad |
 | Catherine Missal | .... | Adena |
 | Ron Livingston | .... | Ethan |
 | Norman Reedus | .... | Trucker |
 | Keegan-Michael Key | .... | Jack Peterson |
 | Regina Hall | .... | Nancy Peterson |
 | E'myri Crutchfield | .... | Sheila Peterson |
 | Alkoya Brunson | .... | Gary Peterson |
 | Nick Kroll | .... | Colorado Cop |
 | Tim Heidecker | .... | Utah Cop |
 | Kaitlin Olson | .... | Arizona Cop |
 | Michael Peña | .... | New Mexico Cop |
 | Hannah Davis | .... | Ferrari Girl |
 | David Clennon | .... | Harry Co-Pilot |
 | Colin Hanks | .... | Jake |
 | Kirstin Ford | .... | Mom on Plane |
 | Ethan Maher | .... | Boy on Plane |
 | Elizabeth Gillies | .... | Heather |
 | Cristina Squyres | .... | Brooke |
 | Nadine Avola | .... | Chelsea |
 | Ryan Cartwright | .... | Terry |
 | Valerie Payton | .... | Shuttle Driver |
 | O'Clair Alexander | .... | Husky Lady at Monument |
 | Miles Doleac | .... | Man at Monument |
 | Holly Gardner | .... | Woman at Monument |
 | R. F. Daley | .... | Furious Husband |
 | Elizabeth Fendrick | .... | Furious Wife |
 | Michael H. Cole | .... | Male Guest #1 |
 | Brooke Jaye Taylor | .... | Female Guest #1 |
 | Matthew Cornwell | .... | Male Guest #2 |
 | Mitchell Warren | .... | Wally World Kid #2 |
 | John Francis Daley | .... | Ride Operator |
 | Kati Akins | .... | Tri Pi Sorority Girl (uncredited) |
 | Libby Blanton | .... | Boobs Woman (uncredited) |
 | Igor Bondaruk | .... | Fraternity Guy (uncredited) |
 | Devlon Chandler Jr. | .... | Park Visitor (uncredited) |
 | Arinitra Chandler | .... | Park Visitor (uncredited) |
 | Ashuntyonna Chandler | .... | Park Visitor (uncredited) |
 | Tarik Chernet | .... | EMT Paramedic (uncredited) |
 | Marshall Choka | .... | Man in Balloon Suit / Drummer (uncredited) |
 | Saundra Coller | .... | Festival Dancer (uncredited) |
 | John Crosby | .... | Airport Traveler (uncredited) |
 | Nancy DeMars | .... | Airplane Passenger (uncredited) |
 | Hunter Denoyelles | .... | Festival Dancer (uncredited) |
 | Saige Donaldson | .... | Airport Traveler (uncredited) |
 | Dawn Douglas | .... | Bodypaint Woman (uncredited) |
 | Sacha A. Dzuba | .... | Speedo Gigolo (uncredited) |
 | Rick Ericson | .... | Hawaiian (uncredited) |
 | Gregory Fears | .... | EMT (uncredited) |
 | Fred Galle | .... | Four Corners Man (uncredited) |
 | Tahseen Ghauri | .... | Airport Traveler (uncredited) |
 | Jessica Lindsey Gilbert | .... | Bikini Dancer (uncredited) |
 | Eric Gladstone | .... | Bear (uncredited) |
 | Jeff Glover | .... | Wally World Dad (uncredited) |
 | Faneal Godbold | .... | Police Officer (uncredited) |
 | Jonathan Goldstein | .... | Hot Tub Guy (uncredited) |
 | Brandon Michael Hale | .... | Gas Station Clerk (uncredited) |
 | Caitlin Halliburton | .... | Disappointed Family (uncredited) |
 | Jas Hardy | .... | Raver Chick (uncredited) |
 | Rory Healy | .... | Festival Partier (uncredited) |
 | Walter Hendrix III | .... | Police Officer (uncredited) |
 | Kimberly Hester Huffstetler | .... | Airport Crowd with Car (uncredited) |
 | Ethan Jago | .... | Firefighter (uncredited) |
 | Barry W. Jerald Jr. | .... | Festival Goer (uncredited) |
 | Catherine Jerald | .... | Festival Goer (uncredited) |
 | Marie Joelyn | .... | Disappointed Family (uncredited) |
 | Emily Kincaid | .... | Young Debbie Griswold (uncredited) |
 | Shere Ladd | .... | Airport Traveler (uncredited) |
 | Omar Lagudali | .... | Reporter (uncredited) |
 | Amanda Leigh | .... | Festival Goer (uncredited) |
 | Samm Levine | .... | Festival Dude Sam (uncredited) |
 | Rick Lite | .... | Park Ranger (uncredited) |
 | Eric McCrea | .... | Fraternity Guy (uncredited) |
 | Cameron James McIntyre | .... | Young James (age 7-9) (uncredited) |
 | Ryan McNeil | .... | Airport Traveler (uncredited) |
 | Dana Clark McPherson | .... | Monument Man (uncredited) |
 | Roger Neal | .... | Frat Guy (uncredited) |
 | Pedro Nicanor | .... | Body Paint Model (uncredited) |
 | Kevin J. O'Connor | .... | Festival Partier (uncredited) |
 | M. V. Oliphant | .... | Nudist (uncredited) |
 | Paul Michael Pouler | .... | Festival Guy with Mohawk / Airport Traveler (uncredited) |
 | Andrew Raffelson | .... | Drummer (uncredited) |
 | Tina Redmond | .... | Airport Traveler (uncredited) |
 | Anthony J Sacco | .... | Airport Traveler (uncredited) |
 | Patti Schellhaas | .... | Upscale Driver (uncredited) |
 | Joe Seo | .... | Navigation (uncredited) |
 | Blake Sewell | .... | Firefighter (uncredited) |
 | Carla Shinall | .... | Rave Girl (uncredited) |
 | Dianne Starkey | .... | Drummer (uncredited) |
 | Carol Anne Taylor | .... | Airport Traveler (uncredited) |
 | Mike Taylor | .... | Airport Traveler (uncredited) |
 | Ruben Vidal | .... | Firefighter / Airport Traveler / Jesterman (uncredited) |
 | Deborah Wilkins | .... | Four Corners Woman (uncredited) |