| Melissa McCarthy | .... | Tammy |
| Susan Sarandon | .... | Pearl |
| Kathy Bates | .... | Lenore |
| Allison Janney | .... | Deb |
| Dan Aykroyd | .... | Don |
| Mark Duplass | .... | Bobby |
| Gary Cole | .... | Earl |
| Nat Faxon | .... | Greg |
| Toni Collette | .... | Missi |
| Sandra Oh | .... | Susanne |
| Ben Falcone | .... | Keith Morgan |
| Sarah Baker | .... | Becky |
| Rich Williams | .... | Larry |
| Steve Little | .... | Jet Ski Rental Guy |
| Dakota Lee | .... | Kathleen |
| Mark L. Young | .... | Jesse |
| Mia Rose Frampton | .... | Karen |
| Steve Mallory | .... | Cashier |
| Big Al Hall | .... | Possum Creek Bluegrass Band |
| Jones Smith | .... | Possum Creek Bluegrass Band |
| Joe Baxter | .... | Possum Creek Bluegrass Band |
| Benjamin Chontos | .... | Possum Creek Bluegrass Band |
| Sean Gould | .... | Possum Creek Bluegrass Band |
| Keith Welborn | .... | DJ |
| Oscar Gale | .... | Javier |
| Justin Smith | .... | Paramedic |
| Willie Hill | .... | Prison Guard |
| Zach Hanner | .... | Man at Blue Post Bar-B-Que |
| Jason Vail | .... | Man at Blue Post Bar-B-Que |
| Leon Lamar | .... | Old Man with Walker |
| Larry Dorf | .... | Officer Mannis |
| Ricky Muse | .... | Officer Curtis |
| Barbara Weetman | .... | Officer Carty |
| William Flaman | .... | La Grange Bail Cop |
| Rey Hernandez | .... | Cop at Lakehouse |
| Penn Charles Holderness | .... | News Anchor |
| Michelle Li | .... | News Reporter |
| Raven Angeline Whisnant | .... | Charlotte |
| Damon Jones | .... | Jerry Miller |
| Sandy McCarthy | .... | Two Old Ladies Leaving a Bar |
| Margo Passas | .... | Two Old Ladies Leaving a Bar |
| Jamar Allen | .... | Cook (uncredited) |
| Alkoya Brunson | .... | Playground Kid #1 |
| Andrea Alcorn | .... | Daughter (uncredited) |
| James Alcorn | .... | Teen Boy (uncredited) |
| Leila Arafat | .... | Waitress at Bar (uncredited) |
| Laura Avery | .... | 4th of July Partier (uncredited) |
| Rochelle Aycoth | .... | Party Go-er (uncredited) |
| Steve Baldwin | .... | Vendor at Lake (uncredited) |
| Katie Barber | .... | Bar Patron / 4th of July Partier (uncredited) |
| Alyssa Bauman | .... | Police Officer (uncredited) |
| Kelly Bisner | .... | Dancer (uncredited) |
| Shannon Blackledge | .... | 4th of July Partier (uncredited) |
| Kristi Booher | .... | July 4th Party Guest (uncredited) |
| Huck Borden | .... | Town Child (uncredited) |
| Caitlyn Brarens | .... | Restaurant Patron (uncredited) |
| Jack Brarens | .... | Camper (uncredited) |
| Sheila Brothers | .... | Connie (uncredited) |
| Rusty Burrow | .... | Nursing Home Staff (uncredited) |
| Roxanne Bush | .... | Blue Post Bar Patron (uncredited) |
| John Carter | .... | Bar Patron (uncredited) |
| Mia Clarke | .... | Teen at Lake (uncredited) |
| Zoe Clarke | .... | Little Girl at Restaurant Counter (uncredited) |
| Robert Gregory Cole | .... | Dancer (uncredited) |
| Kevin M. Conte | .... | Diner Family (uncredited) |
| Rita Conte | .... | Grandmother (uncredited) |
| Christopher Cozort | .... | Blue Post Customer (uncredited) |
| Carol Crandall | .... | Restaurant Patron (uncredited) |
| Todd Davis | .... | Police Officer (uncredited) |
| Illie Dawson | .... | Officer Glen (uncredited) |
| Dale Deacon | .... | Nursing Home Staff (uncredited) |
| Jonathan Edwards | .... | Blue Post Customer (uncredited) |
| Cricket Ellis | .... | Lunchroom Lady (uncredited) |
| Kaitlyn Ervin | .... | Lake Teen (uncredited) |
| Carolyn Foland | .... | Dancer (uncredited) |
| William Frasca | .... | Subaru Driver at Gas Station (uncredited) |
| Tom Gore | .... | Dancer (uncredited) |
| Randy Grazio | .... | Police Officer (uncredited) |
| Clare Halstead | .... | Topper Jack's Customer (uncredited) |
| Mary Beth Hawkins | .... | Dancer (uncredited) |
| Lemuel Heida | .... | Bar Patron (uncredited) |
| Patricia Hewitt | .... | Market Patron (uncredited) |
| Jeff Hill | .... | Francis the Fast Food Worker (uncredited) |
| Joseph Milton Hodges Jr. | .... | Assisted Living Staff (uncredited) |
| Joseph Milton Hodges Sr. | .... | Assisted Living Resident (uncredited) |
| Nancy Rouse Hodges | .... | Assisted Living Resident (uncredited) |
| Gerald Jackson | .... | Vendor (uncredited) |
| Mary-Jo Jackson | .... | Market Folk (uncredited) |
| Ben Joyce | .... | Topper Jack's Customer (uncredited) |
| Caroline Kahn | .... | Market Person (uncredited) |
| Emily E. Kelly | .... | Townfolk (uncredited) |
| Natasha Key | .... | Bar patron (uncredited) |
| Randi Langdon | .... | Niagara Falls Tourist (uncredited) |
| Henry Lawrence | .... | Restaurant Diner (uncredited) |
| Karen Malina | .... | Blue Post Bar Patron (uncredited) |
| Chris Matheny | .... | Pedestrian with Car (uncredited) |
| Donna McGinnis Salberg | .... | Waitress (uncredited) |
| William t. McGregor | .... | Bar Dancer (uncredited) |
| John Merical | .... | Retirement Home Visitor (uncredited) |
| Brian Patrick Moize | .... | Topper Jack Patron (uncredited) |
| Joe Montanti | .... | Great Dane Walker (uncredited) |
| David Andrew Nash | .... | Morningside Guard (uncredited) |
| James Nass | .... | Grandparent (uncredited) |
| David Pascua | .... | Tourist (uncredited) |
| Matt Perkinson | .... | Park Patron (uncredited) |
| Danecka Peyton | .... | Staff Server (uncredited) |
| Namiah Potter | .... | Leland House Clerk (uncredited) |
| Kathy Walton Pulley | .... | Blue Post Customer (uncredited) |
| Darrell Rackley | .... | (uncredited) |
| Tammy Rackley | .... | Coffee Vendor at Park (uncredited) |
| Selena V. Raffaele | .... | 4th of July Party Goer (uncredited) |
| Michelle Rivera | .... | Arresting Cop (uncredited) |
| J. R. Rodriguez | .... | Kentucky Trooper (uncredited) |
| Katie Sawhill | .... | Lady in Bathroom (uncredited) |
| David Schifter | .... | Drunk Single Guy (uncredited) |
| Paul Shaplin | .... | Cook (uncredited) |
| Amy Smith | .... | 4th of July Partygoer (uncredited) |
| Marie Sokol | .... | Pedestrian (uncredited) |
| Rob Springer | .... | Gene the Cook (uncredited) |
| Carol Stephans | .... | Party Goer (uncredited) |
| Alexia Stip | .... | Playground Kid (uncredited) |
| Kent Sublette | .... | Carl Judy (uncredited) |
| Kristina Tonkowska | .... | Camper (uncredited) |
| Shelby Townsend | .... | Canoe Teen (uncredited) |
| Patrick Veihmeyer | .... | Bar Patron (uncredited) |
| A. J. Verel | .... | Tourist (uncredited) |
| Jett Walker | .... | Lake Child (uncredited) |
| Diana Ward | .... | Lake Teen (uncredited) |
| Angela Marie Williams | .... | Market Shopper (uncredited) |
| Ben Yemba | .... | Prison Guard (uncredited) |
| Julie Zimmer | .... | Market Woman (uncredited) |