 | Dustin Hoffman | .... | Bernard 'Bernie' Laplante |
| Geena Davis | .... | Gale Gayley, Channel 4 News Reporter |
| Andy Garcia | .... | John Bubber |
| Joan Cusack | .... | Evelyn Laplante |
| Kevin J. O'Connor | .... | Chucky, Channel 4 News Cameraman |
| Maury Chaykin | .... | Winston, Bernie's Landlord |
| Stephen Tobolowsky | .... | James Wallace, Channel 4 Station Manager |
| Christian Clemenson | .... | James Conklin, Channel 4 News Reporter |
| Tom Arnold | .... | Chick, Bartender |
| Warren Berlinger | .... | Judge Goines |
| Cady Huffman | .... | Flight Attendant Leslie Sugar |
| Susie Cusack | .... | Donna O'Day, Bernie's Public Defender |
| James Madio | .... | Joey Laplante, Bernie's Son |
| Richard Riehle | .... | Robinson, Bernie's Boss |
| Daniel Leroy Baldwin | .... | Fireman Denton |
| Don Yesso | .... | Elliott the Fireman, Evelyn's Boyfriend |
| Don Pugsley | .... | Jury Foreman |
| Lee Wilkof | .... | Prosecutor |
| Steven Elkins | .... | First Bailiff |
| Leslie Jordan | .... | Court Official |
| Raymond Fitzpatrick | .... | Second Bailiff |
| Bobby C. Collins | .... | Mendoza |
| Richard Montoya | .... | Vargas |
| Ric Salinas | .... | Mendoza's Friend |
| Herbert Siguenza | .... | Espinosa |
| Don S. Davis | .... | Probation Officer |
| Darrell Larson | .... | Flight Attendant Freddy King |
| Harry Northup | .... | Mr. Fletcher, Flight 104 Survivor |
| Jordan Bond | .... | Richie Fletcher, Flight 104 Survivor |
| Eric Poppick | .... | Mr. Smith, Flight 104 Survivor |
| Julia Barry | .... | Kelly, Flight 104 Survivor |
| Marnie Mosiman | .... | Susan |
| William Duff Griffin | .... | Mr. Brown |
| Peggy Roeder | .... | Bag Lady on TV |
| Katrina Cerio | .... | Makeup Artist |
| Kevin Jackson | .... | Inspector Dayton, Robbery Detail |
| Don Gazzaniga | .... | Fire Captain |
| Lance Kinsey | .... | Paramedic |
| Michael Talbott | .... | State Police Officer at Crash Site |
| John Ackerman | .... | Bag Man |
| Paul Hewitt | .... | Parker |
| Marita Geraghty | .... | Joan |
| Shirley Pierce | .... | Anchorwoman - Channel 4 |
| Sam Derence | .... | Reporter - Channel-8 |
| Rick Plastina | .... | Reporter - Channel 13 |
| Martin Schienle | .... | Allen in Coma |
| Jeff Garlin | .... | News Vendor |
| John M. Watson Sr. | .... | African American Wannabee |
| John Mohrlein | .... | Fighter Wannabee |
| Tony Fitzpatrick | .... | Fighter Wannabee |
| Vito D'Ambrosio | .... | Another Wannabee |
| Jay Leggett | .... | Mud Face Wannabee |
| Dev Kennedy | .... | Tall Wannabee |
| Darryl Davis | .... | Tough Prisoner |
| Terry Muller | .... | Tough Prisoner |
| James Alfred Whitaker | .... | Tough Prisoner |
| Collins Williams Daniels | .... | Rasta Prisoner |
| I. M. Hobson | .... | Waiter / Captain |
| William Newman | .... | Millionaire |
| Clea Lewis | .... | Sylvia, Autograph Girl |
| Jeff Kline | .... | Street Kid |
| John Merrill | .... | Street Kid |
| Lynn Oddo | .... | Buxom Woman |
| Milton L. Cobb | .... | Vietnam Vet |
| Robert Pabst | .... | Vietnam Vet |
| Tom Milanovich | .... | Guard at Jail |
| Cordis Heard | .... | Nurse Roberts |
| Mandy Duncan | .... | Teen in Hospital |
| Gerardo Murillo-Carr | .... | Teen in Hospital |
| Henry Brown | .... | Hospital Guard |
| Robert Munns | .... | Doctor |
| Tamar Teufenkjian | .... | Child in Hospital |
| Jose Reyes | .... | Child in Hospital |
| Michael Mullen | .... | Child in Hospital |
| D'Angelo Ferreri | .... | Child in Hospital |
| Kody Cullum | .... | Child in Hospital |
| Heidi McNeal | .... | Teenage Girl at Hospital |
| Michael O'Dwyer | .... | Cop at Hospital |
| Ed Scheibner | .... | Donna's Boyfriend |
| James Callahan | .... | Police Chief |
| D. David Morin | .... | Fireman on Ledge |
| Dan Healy | .... | George Bush Look A-Like |
| Margery Jane Ross | .... | Barbara Bush Look A-Like |
| Mike Akrawi | .... | Autograph hound (uncredited) |
| Suzy Brack | .... | Crying Woman (uncredited) |
| John Brennan | .... | Channel 4 News Assistant (uncredited) |
| Ernest Capponi | .... | Bit (uncredited) |
| Chevy Chase | .... | Deke, Channel 4 News Director (uncredited) |
| Edward Herrmann | .... | Mr. Broadman, Suicide (uncredited) |
| Barney Martin | .... | Court Official (uncredited) |
| Larry Nazimek | .... | Reporter (uncredited) |
| John Nesci | .... | Police Officer (uncredited) |
| Fisher Stevens | .... | Director of Channel 4 Crash Feature (uncredited) |
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