| Keanu Reeves | .... | John Wick |
| Riccardo Scamarcio | .... | Santino D'Antonio |
| Ian McShane | .... | Winston |
| Ruby Rose | .... | Ares |
| Common | .... | Cassian |
| Claudia Gerini | .... | Gianna D'Antonio |
| Lance Reddick | .... | Charon |
| Laurence Fishburne | .... | Bowery King |
| Tobias Segal | .... | Earl |
| John Leguizamo | .... | Aurelio |
| Bridget Moynahan | .... | Helen |
| Thomas Sadoski | .... | Jimmy |
| Erik Frandsen | .... | Numismatic |
| David Patrick Kelly | .... | Charlie |
| Perry Yung | .... | Doctor |
| Franco Nero | .... | Julius |
| Youma Diakite | .... | Lucia |
| Peter Serafinowicz | .... | Sommelier |
| Luca Mosca | .... | Italian Tailor |
| Midori Nakamura | .... | Seamstress |
| Mario Donatone | .... | Cardinal |
| Giorgio Carminati | .... | Priest |
| Elli Meyer | .... | Pawnbroker |
| Thaddeus Daniels | .... | Nigerian |
| Margaret Daly | .... | Operator |
| Christine Hollingsworth | .... | Bartender |
| Ciscandra Nostalghia | .... | Concert Singer |
| Chukwudi Iwuji | .... | Akoni |
| Peter Stormare | .... | Abram |
| Vadim Kroll | .... | Cheslav |
| Simone Spinazzč | .... | Cartographer |
| Chris LaPanta | .... | Earl's Guard #1 |
| Guyviaud Joseph | .... | Earl's Guard #2 |
| Diane Gooch | .... | Waitress |
| Alisa Ermolaev | .... | Switchboard Operator #1 |
| Kelly Rae LeGault | .... | Switchboard Operator #2 |
| Wass Stevens | .... | Consiglieri |
| Joan Smalls | .... | Continental Female Assassin |
| Basil Iwanyk Sr. | .... | Creepy Homeless Man |
| Peter Arpesella | .... | Italian Guest (uncredited, voice) |
| Aaron Ayhan | .... | Assassin (uncredited) |
| Sidney Beitz | .... | Bartender (uncredited) |
| Joel Brody | .... | Undercover Homeless Man (uncredited) |
| Marko Caka | .... | Businessman (uncredited) |
| Nancy Cejari | .... | Business Woman (uncredited) |
| Garrett Ching | .... | Triad Big Boss (uncredited) |
| Aaron Cohen | .... | Hitman (uncredited) |
| Victor Competiello | .... | Italian Tailor (uncredited) |
| Tim Connolly | .... | Ares Team #2 (uncredited) |
| Marmee Regine Cosico | .... | ND Chinatown Pedestrian (uncredited) |
| Kitty Crystal | .... | Switchboard Operator (uncredited) |
| Jennifer Dong | .... | Cocktail Waitress (uncredited) |
| Anthony Romeo Garcia | .... | Tourist (uncredited) |
| Daniel Garcia | .... | Parent (uncredited) |
| Patricia Hodges | .... | Wall Street Businesswoman (uncredited) |
| Faith Logan | .... | Bar Patron (uncredited) |
| Aly Mang | .... | Winston's Personal Assistant (uncredited) |
| Doris McCarthy | .... | Park Lady (uncredited) |
| Gary McNerney | .... | Suburban Father (uncredited) |
| Frank Modica | .... | Park Goer / Assassin (uncredited) |
| Heidi Moneymaker | .... | Assassin (uncredited) |
| Stephanie Ng Wan | .... | Sumo Assassin's Girlfriend (uncredited) |
| Johnny Otto | .... | Assassin (uncredited) |
| Angel Pai | .... | Assassin (uncredited) |
| Christopher Parker | .... | Garbage Man #1 (uncredited) |
| Oleg Prudius | .... | Russian Assassin (uncredited) |
| Shade Rupe | .... | Opera Attendee (uncredited) |
| Kenny Sheard | .... | Ares Team (uncredited) |
| Nobuya Shimamoto | .... | Assassin (uncredited) |
| Nora Sommerkamp | .... | Hotel Guest / Assassin (uncredited) |
| Emmanuel Todorov | .... | Russian Cabbie (uncredited, voice) |
| Nico Toffoli | .... | Brian Blackman (uncredited) |
| Mark Vincent | .... | Winston's Guard (uncredited) |
| Dametri F. Wabby | .... | Santino's Crew Member (uncredited) |
| Bill Walters | .... | Homeless Man in Chinatown (uncredited) |
| Justin L. Wilson | .... | Special Ops Assassin (uncredited) |
| McManus Woodend | .... | Bowery King Bodyguard (uncredited) |
| John Robert Woodlock | .... | Assassin (uncredited) |
| Yama | .... | Sumo Assassin (uncredited) |
| Alex Ziwak | .... | Russian Gunman (uncredited) |