| Liam Hemsworth | .... | Jake Morrison |
| Jeff Goldblum | .... | David Levinson |
| Jessie T. Usher | .... | Dylan Hiller |
| Bill Pullman | .... | President Whitmore |
| Maika Monroe | .... | Patricia Whitmore |
| Sela Ward | .... | President Lanford |
| William Fichtner | .... | General Adams |
| Judd Hirsch | .... | Julius Levinson |
| Brent Spiner | .... | Dr. Brakish Okun |
| Patrick St. Esprit | .... | Secretary of Defense Tanner |
| Vivica A. Fox | .... | Jasmine Hiller |
| Angelababy | .... | Rain Lao |
| Charlotte Gainsbourg | .... | Catherine Marceaux |
| DeObia Oparei | .... | Dikembe Umbutu |
| Nicolas Wright | .... | Floyd Rosenberg |
| Travis Tope | .... | Charlie Miller |
| Chin Han | .... | Commander Jiang |
| Gbenga Akinnagbe | .... | Agent Travis |
| Robert Loggia | .... | General Grey |
| John Storey | .... | Dr. Isaacs |
| Joey King | .... | Sam |
| Jenna Purdy | .... | Sphere (voice) |
| Garrett Wareing | .... | Bobby |
| Hays Wellford | .... | Felix |
| McKenna Grace | .... | Daisy |
| James Andre Woods | .... | Lt. Ritter |
| Robert Neary | .... | Captain McQuade |
| Joshua Mikel | .... | Armand |
| Joel Virgel | .... | Jaques |
| Arturo Del Puerto | .... | Bordeaux |
| Matt Munroe | .... | Prison Tech |
| Jacob Browne | .... | Prison Tech |
| Ryan Cartwright | .... | David's Assistant |
| Travis Hammer | .... | Jeffrey Fineman |
| Lance Lim | .... | Camper Kevin |
| Zeb Sanders | .... | Camper Henry |
| Donovan Tyee Smith | .... | Camper Marcus |
| Stafford Douglas | .... | Flight Officer |
| Jade Scott Lewis | .... | Salt Flat Tech |
| Beth Bailey | .... | DC Hospital Nurse |
| Mona Malec | .... | DC Hospital Nurse |
| Omar Diop | .... | African Guard |
| Ron Yuan | .... | Weapons Engineer |
| Grace Huang | .... | Female Technician |
| Stephen Oyoung | .... | Young Man |
| J. P. Murrieta | .... | Local Reporter |
| Casey Messer | .... | Local Reporter |
| Ben Wang | .... | Chinese President |
| Nicholas Ballas | .... | French President |
| Jonathan Richards | .... | British Prime Minister |
| Ivan Gvera | .... | Russian President |
| Michael Davis | .... | Old Man with Oxygen |
| Brandon K. Hampton | .... | Officer |
| Sam Quinn | .... | Radar Officer |
| Shad Adair | .... | Aide to Sec of Defense Tanner (uncredited) |
| Valerie Adams | .... | Pedestrian (uncredited) |
| Lorus Allen | .... | Area 51 Flagman (uncredited) |
| Mark S. Allen | .... | Journalist (uncredited) |
| Toney Anton | .... | ESD Tech / Ground Crew (uncredited) |
| Aurora Antonio | .... | Teenager (uncredited) |
| Justin Arnsworth | .... | Fighter Pilot (uncredited) |
| Nathaniel Augustson | .... | Gas Station Attendant (uncredited) |
| Robert O. Baker | .... | Press Corp / Washington Dignitary (uncredited) |
| Colt Balok | .... | Area 51 Soldier (uncredited) |
| Brian Barela | .... | Area 51 Soldier (uncredited) |
| Wren Barnes | .... | Girl Driving Her Car Away from Chaos (uncredited) |
| Richard Beal | .... | Military Brass (uncredited) |
| Ciara Bergman | .... | ESD Tech (uncredited) |
| Todd Bethke | .... | Airline Passenger (uncredited) |
| Morse Bicknell | .... | Russian Commander (uncredited) |
| Steven Blacksmith | .... | Orderly (uncredited) |
| Andrew James Bleidner | .... | Area 51 Soldier (uncredited) |
| Brian Bolman | .... | ESD Medical Personnel (uncredited) |
| Dante Briggins | .... | Area 51 Soldier (uncredited) |
| Nathan Brimmer | .... | Cheyenne Mountain Security (uncredited) |
| Edward Butron | .... | Moon Base Tech (uncredited) |
| Monique Candelaria | .... | Tech Officer (uncredited) |
| Paul Caster | .... | RV Driver (uncredited) |
| Leilei Chen | .... | Background (uncredited) |
| Gabrielle Chevalier | .... | Civilian Child - Extra (uncredited) |
| Jeremie Dalaba | .... | Area 51 ESD Tech (uncredited) |
| Ava Del Cielo | .... | Young Mother (uncredited) |
| David Devereaux | .... | Military Aide #1 (uncredited) |
| Faber Dewar | .... | Flight Commander (uncredited) |
| Jetto Dorsainville | .... | Salt Flats Tech / Area 51 Soldier (uncredited) |
| Edward A. Duran | .... | Orbital tech #2 (uncredited) |
| Mark Falvo | .... | News Reporter (uncredited) |
| Marlon V. Gaines | .... | Driver (uncredited) |
| Diana Gaitirira | .... | Comms Officer (uncredited) |
| Gerry Garcia | .... | Bus Boy (uncredited) |
| Tahseen Ghauri | .... | Area 51 ESD Scientist (uncredited) |
| Lawrence Gilligan | .... | President Aide (uncredited) |
| Alison Grainger | .... | Gas Station Customer (uncredited) |
| Evan Bryn Graves | .... | Pilot P. Goodman (uncredited) |
| William Greely | .... | Area 51 Tech (uncredited) |
| Sylvie Grontis Hagan | .... | Scientist (uncredited) |
| Stephen M. Hardin | .... | Tug Pilot (uncredited) |
| Crystal Harris | .... | Woman Driving Away from Chaos (uncredited) |
| Jason E. Hill | .... | Marine (uncredited) |
| Landon Hill | .... | Bus Passenger (uncredited) |
| Alan Humphrey | .... | Press Corps (uncredited) |
| Raiden Integra | .... | Press Corps (uncredited) |
| Patrick Juarez | .... | Area 51 Officer (uncredited) |
| Jamie H. Jung | .... | Ground Crew (uncredited) |
| Jade Kammerman | .... | Orbital Tech (uncredited) |
| Cory Kapahulehua | .... | Moon Base Tug Pilot (uncredited) |
| Harrison Kavanaugh | .... | ESD Tech (uncredited) |
| Katrina Kavanaugh | .... | ESD Tech (uncredited) |
| Sal Koussa | .... | Window Washer (uncredited) |
| Tyler Kurtz | .... | Pilot (uncredited) |
| Tom Kwiat | .... | Pvt. Ian Jennings (uncredited) |
| Josh LaCombe | .... | Area 51 Tech (uncredited) |
| Jonathan Lane | .... | Press Corps (uncredited) |
| Dom Dela Cruz Languit | .... | Moon Base Crew (uncredited) |
| Andrei Lapionak | .... | Russian Cosmonaut (uncredited) |
| Steve Larese | .... | Washington D.C. Dignitary (uncredited) |
| Shawn Lecrone | .... | Pvt. T. Ferguson / Area 51 Soldier (uncredited) |
| Kenny Leu | .... | Ping Li (uncredited) |
| Cajardo Lindsey | .... | Camera Operator (uncredited) |
| Audrey Loggia | .... | Astrid Grey (uncredited) |
| Justin Lotz | .... | Gas Station Patron (uncredited) |
| David Loving | .... | DC Dignitary (uncredited) |
| Kelly V. Lucio | .... | Singapore Pedestrian (uncredited) |
| Jonathan Lund | .... | Scientist #1 (uncredited) |
| Jon McGarrah | .... | Area 51 Ground Crew (uncredited) |
| Monique McKellop | .... | Dignitary Müller (uncredited) |
| David Melendez | .... | Prison Tech (uncredited) |
| David Miller | .... | USAF 2d Lt Hamm (uncredited) |
| Justin D. Moore | .... | Hospital visitor / WA DC Dignitary (uncredited) |
| Victoria L. Moya | .... | ESD Soldier / Hospital Patient (uncredited) |
| Jack Nolan | .... | London Civilian (uncredited) |
| Hans Obma | .... | Sokolov (uncredited) |
| Vaughn Odenbrett | .... | Angry Driver in Volvo Pulling Trailer (uncredited) |
| Johnny Otto | .... | Secret Service Agent (uncredited) |
| Akshay Patel | .... | Dylan's Pilot (uncredited) |
| Daniel Pattison | .... | Area 51 Fighter Pilot (uncredited) |
| Julian Petersen | .... | Fighter Pilot / Military Soldier (uncredited) |
| Kyle Pierson | .... | Area 51 / ESD Ground Crew (uncredited) |
| Catharine Pilafas | .... | Flight Officer #3 (uncredited) |
| Daniel Pimentel | .... | Secret Service Agent (uncredited) |
| Tiffany Quilter | .... | Driver fleeing invasion (uncredited) |
| Grizelda Quintana | .... | Road Rage / Confrontation Driver (uncredited) |
| Dave Racki | .... | Chopper Pilot (uncredited) |
| Diezel Ramos | .... | Area 51 Soldier (uncredited) |
| Alice Rietveld | .... | Secret Service Agent (uncredited) |
| Ryan Baloy Rivera | .... | SGT P. Howard (uncredited) |
| Chris Romrell | .... | Moon Base Tech (uncredited) |
| Anthony J Sacco | .... | Hospital visitor (uncredited) |
| Clayton Salberg | .... | Area 51 Fighter Pilot (uncredited) |
| Brent Wayne Sanders | .... | Moon Base Tug Pilot (uncredited) |
| Joseph P. Santillanes | .... | President Staff (uncredited) |
| Gabriel Schmidt | .... | Driver (uncredited) |
| Jack T. Silliman | .... | Area 51 Tech Security (uncredited) |
| Christian Simpson | .... | Sgt. Fletcher Smith (uncredited) |
| Jeremy Sims | .... | Area 51 Technician (uncredited) |
| Alma Sisneros | .... | Aide 2 (uncredited) |
| Corey Sondrup | .... | Driver (uncredited) |
| Phil Sperandeo | .... | Area 51 Soldier (uncredited) |
| David Stanford | .... | Washington D.C. Dignitary (uncredited) |
| Michael E. Stogner | .... | Press Corps (uncredited) |
| Aaron Templeton | .... | Area 51 Solider (uncredited) |
| Michael Love Toliver | .... | Moon Base Tech (uncredited) |
| Aaron Tyler | .... | Tug Pilot (uncredited) |
| Gregory Paul Valdez | .... | Press Corps (uncredited) |
| McKenna Wagenman | .... | Gas Station Kid (uncredited) |
| Shannan Wagenman | .... | Gas Station Patron (uncredited) |
| Taylor Wagenman | .... | Hospital Kid (uncredited) |
| Jerry Walker | .... | Milky Eye Guard (uncredited) |
| Rooter Wareing | .... | White House Staffer (uncredited) |
| Nate Warren | .... | Marley Sullivan (uncredited) |
| Joe Warshaw | .... | Sgt 1st Class Miller (uncredited) |
| Robert Douglas Washington | .... | Dirk Strickland (uncredited) |
| Charles Adam West | .... | Scientist #2 (uncredited) |
| Jeffrey M. Williams | .... | Patricia Squadron Pilot (uncredited) |
| Danny Winn | .... | DC Dignitary (uncredited) |
| Otis Winston | .... | Brian Cole (uncredited) |
| Benjamin Isaiah Wolfe | .... | DC Dignitary (uncredited) |
| Julian Wondolowski | .... | Driver with Vehicle Bugging Out (uncredited) |