| Liam Neeson | .... | Bill Marks |
| Julianne Moore | .... | Jen Summers |
| Scoot McNairy | .... | Tom Bowen |
| Michelle Dockery | .... | Nancy |
| Nate Parker | .... | Zack White |
| Corey Stoll | .... | Austin Reilly |
| Lupita Nyong'o | .... | Gwen |
| Omar Metwally | .... | Dr. Fahim Nasir |
| Jason Butler Harner | .... | Kyle Rice |
| Linus Roache | .... | David McMillan |
| Shea Whigham | .... | Agent Marenick |
| Anson Mount | .... | Jack Hammond |
| Quinn McColgan | .... | Becca |
| Corey Hawkins | .... | Travis Mitchell |
| Frank Deal | .... | Charles Wheeler |
| Bar Paly | .... | Iris Marianne |
| Edoardo Costa | .... | Herve Philbert |
| Jon Abrahams | .... | David Norton |
| Amanda Quaid | .... | Emily Norton |
| Beth Dixon | .... | Older Woman |
| Cameron Moir | .... | Steward |
| Lars Gerhard | .... | German Father |
| Oliver Lehne | .... | German Son |
| Michael Thomas Walker | .... | Michael Tate |
| Pat Kiernan | .... | NY1 Anchor |
| Annika Pergament | .... | NY1 Reporter |
| Victoria Arbiter | .... | Tilkynna 3 Reporter |
| Jefrey Pollock | .... | Pundit |
| Hank Sheinkopf | .... | Pundit |
| Dani de Waal | .... | Airline Attendant |
| Adi Hanash | .... | Security Officer |
| Andrew Alberson | .... | Core Plane Passenger (uncredited) |
| Finise Avery | .... | Core Plane Passenger (uncredited) |
| Marshall Axt | .... | Core Plane Passenger (uncredited) |
| Ari Barkan | .... | Plane Passenger (uncredited) |
| Lorenzo Beronilla | .... | Sky Captain (uncredited) |
| Josh Bodenhamer | .... | Giovanni (uncredited) |
| Nadia Bowers | .... | Mrs. O'Reilly (uncredited) |
| Alejandro Cardenas | .... | Arturo Lucci (uncredited) |
| Kenneth Carrella | .... | Icelandic Police (uncredited) |
| Rob Casasanta | .... | Fire Truck Driver (uncredited) |
| Corey T. Clark | .... | 1st Class Passenger (uncredited) |
| Richard R. Corapi | .... | Fireman (uncredited) |
| Mahnaz Damania | .... | Cashier (uncredited) |
| Jessica Doehle | .... | Reporter (uncredited) |
| Julia M. Ebner | .... | Olivia Marks (Bill's Daughter) (uncredited) |
| Vince Edgehill | .... | Core Plane Passenger (uncredited) |
| O-T Fagbenle | .... | Jack Rabbitte (uncredited, voice) |
| Edgar Felix | .... | Pedestrian (uncredited) |
| Ibnu Firza | .... | Core Plane Passenger (uncredited) |
| Bryan Fox | .... | Core Plane Passenger (uncredited) |
| Brandon Lee Harris | .... | Core Plane Passenger (uncredited) |
| Kelly Hartnett | .... | Core Plane Passenger 14E (uncredited) |
| Christine Hitt | .... | Camila D'Agostino (uncredited) |
| Ken Jacowitz | .... | Core Plane Passenger (uncredited) |
| Ashley James | .... | Technician (uncredited) |
| Michael Kaplan | .... | Passenger (uncredited) |
| Sharlota Kay | .... | Core Plane Passenger (uncredited) |
| Charlotte Kirk | .... | Amy Harris (uncredited) |
| Perri Lauren | .... | Stella (uncredited) |
| Howard Lockser | .... | Business Class Passenger (uncredited) |
| Gregg Micheals | .... | Core Plane Passenger (uncredited) |
| Miou | .... | Core Plane Passenger (uncredited) |
| Bryan A. Miranda | .... | Core Moroccan Plane Passenger (uncredited) |
| John Mitchell | .... | Iceland Police Officer (uncredited) |
| Jessie Nagpal | .... | Business Class Indian Passenger (uncredited) |
| Jennifer Nova | .... | German Daughter (uncredited) |
| Chris Nuñez | .... | Core Plane Passenger (uncredited) |
| Toshiko Onizawa | .... | Woman at the Airport (uncredited) |
| Anthony Pasqua | .... | Iceland Police Officer (uncredited) |
| Frankie Ramos | .... | Core Plane Passenger (uncredited) |
| Dennis Rees | .... | Paramedic (uncredited) |
| Jelayna Rose | .... | Core Plane Passenger (uncredited) |
| Stuart Schnitzer | .... | Core Plane Passenger (uncredited) |
| George Schroeder | .... | Paramedic (uncredited) |
| Rakesh Shah | .... | Core Plane Passenger (uncredited) |
| Nancy Ellen Shore | .... | Core Plane Passenger (uncredited) |
| Robert Shulman | .... | Icelandic Police (uncredited) |
| Jennifer Simard | .... | Maggie Evans (uncredited) |
| Özgür Teke | .... | Business Class Passenger (uncredited) |
| Liz Thomas | .... | Madeline (uncredited) |
| Raquel Toro | .... | Core Plane Passenger (uncredited) |
| Raul Tovar Salazar | .... | Passenger (uncredited) |
| Julie Vera | .... | Economy Passenger (uncredited) |
| Darren Whitfield | .... | Core Plane Passenger (uncredited) |