| Jason Mewes | .... | Jay |
| Kevin Smith | .... | Silent Bob |
| Ben Affleck | .... | Holden McNeil |
| Ben Affleck | .... | Ben Affleck |
| Jeff Anderson | .... | Randal Graves |
| Brian Christopher O'Halloran | .... | Dante Hicks |
| Shannon Elizabeth | .... | Justice |
| Eliza Dushku | .... | Sissy |
| Ali Larter | .... | Chrissy |
| Jennifer Schwalbach | .... | Missy |
| Will Ferrell | .... | Federal Wildlife Marshal Willenholly |
| Jason Lee | .... | Brodie Bruce |
| Jason Lee | .... | Banky Edwards |
| Judd Nelson | .... | Sheriff |
| George Carlin | .... | Hitchhiker |
| Carrie Fisher | .... | Nun |
| Seann William Scott | .... | Brent |
| Jon Stewart | .... | Reg Hartner |
| Jules Asner | .... | Jules Asner |
| Steve Kmetko | .... | Steve Kmetko |
| Tracy Morgan | .... | Pumpkin Escobar |
| Gus Van Sant | .... | Gus Van Sant |
| Chris Rock | .... | Chaka Luther King |
| Jamie Kennedy | .... | Chaka's Production Assistant |
| Wes Craven | .... | Wes Craven |
| Shannen Doherty | .... | Shannen Doherty |
| Mark Hamill | .... | Cocknocker |
| Amy Noble | .... | Silent Bob's Mother |
| Harley Quinn Smith | .... | Baby Silent Bob |
| Ever Carradine | .... | Jay's Mother |
| Brian Andrew Saible | .... | Baby Jay |
| Gavin Brooks | .... | Baby Jay (voice) |
| John Willyung | .... | Passerby |
| Jake Richardson | .... | Teen #1 |
| Nick Fellinger | .... | Teen #2 |
| Vincent Pereira | .... | Quick Stop Customer |
| Ernest O'Donnell | .... | Cop |
| Tango | .... | Suzanne |
| Marc Blucas | .... | The Guy |
| Matthew James | .... | The Dude |
| Jane Silvia | .... | Bookish Girl |
| Carmen Llywelyn | .... | Redhead Beauty |
| Dan Etheridge | .... | Deputy |
| Eric Winzenried | .... | Cop #1 |
| Jonathan Gordon | .... | Cop #2 |
| John Maynard | .... | Cop #3 |
| Robert H. Holtzman | .... | Cop #4 |
| Tom Dorfmeister | .... | Cop #5 |
| Joe Quesada | .... | Pizza Delivery Guy |
| Diedrich Bader | .... | Miramax Security Guard Gordon |
| Scott Mosier | .... | GWH2 Assistant Director |
| Scott Mosier | .... | Willam Black |
| James J. McLauchlin | .... | GWH2 Clapper |
| James J. McLauchlin | .... | Loader |
| Joseph D. Reitman | .... | Bluntman & Chronic Assistant Director |
| Paul Dini | .... | Bluntman & Chronic Clapper |
| Paul Dini | .... | Loader |
| Quentin Wright | .... | William Dusky |
| Gregory Owen | .... | Suburban Kid |
| Ralph Meyer | .... | Receptionist |
| Bryan Johnson | .... | Steve-Dave Pulasti |
| Walter Flannigan | .... | Walt Grover the Fanboy |
| Renée Humphrey | .... | Tricia Jones |
| Joey Lauren Adams | .... | Alyssa Jones |
| Dwight Ewell | .... | Hooper LaMont |
| Alanis Morissette | .... | That Woman (God) |
| Morris Day | .... | Morris Day |
| The Time | .... | Jerome Benton |
| The Time | .... | Garry Johnson |
| The Time | .... | Monte Moir |
| Torrell Ruffin | .... | Torrell Ruffin - Morris Day And The Time |
| Ricky Smith | .... | Ricky Smith- Morris Day And The Time |
| James Van Der Beek | .... | James Van Der Beek |
| Jason Biggs | .... | Jason Biggs (uncredited) |
| Thomas Burke | .... | Blue Collar Man (uncredited) |
| Matt Damon | .... | Matt Damon (uncredited) |
| Matt Damon | .... | Will Hunting (uncredited) |
| William B. Davis | .... | Cigarette Smoking Man (uncredited) |
| Susan Engel | .... | Ben Affleck's Make-Up Artist (uncredited) |
| Stephanie Entin | .... | Convenience Store Girl (uncredited) |
| Cass Franklin | .... | Extra (uncredited) |
| Mark Steven Johnson | .... | Movie Director (uncredited) |
| Demetra Karakostas | .... | Movie Patron Couple (uncredited) |
| Zak Knutson | .... | The C.L.I.T. (uncredited, voice) |
| Corey Scott Levin | .... | Concertgoer (uncredited) |
| Corey Scott Levin | .... | Film Attendee (uncredited) |
| Brian Lynch | .... | Comic Book Shopper #1 (uncredited) |
| David Mandel | .... | Extra (uncredited) |
| Chris McDevitt | .... | Comic Book Shopper #2 (uncredited) |
| Art Oughton | .... | Clapper (uncredited) |
| Art Oughton | .... | Loader (uncredited) |
| John Papp | .... | Movie Patron Couple (uncredited) |
| Derek Raser | .... | Bus Driver (uncredited) |
| Bob Schreck | .... | Gus Van Sant's Assistant (uncredited) |
| Scott Sener | .... | Quiet Scott (uncredited) |
| Rusty Sheridan | .... | Afroed Whitey (uncredited) |
| John Strand | .... | Miramax Security Guard #2 (uncredited) |
| Nicole Vanderhoff | .... | GWH2 Extra Glaring at PA (uncredited) |
| Scott William Winters | .... | Clark (uncredited) |
| Scott William Winters | .... | Scott William Winters (uncredited) |