| Bruce Willis | .... | Frank Moses |
| Mary-Louise Parker | .... | Sarah Ross |
| Karl Urban | .... | William Cooper |
| Rebecca Pidgeon | .... | Cynthia Wilkes |
| Morgan Freeman | .... | Joe Matheson |
| Chris Owens | .... | Hanged Man |
| Jaqueline Fleming | .... | Marna |
| Randy Wade Kelley | .... | Paramedic |
| Jason Giuliano | .... | Endercott |
| Alec Rayme | .... | Cop at Intersection |
| Lawrence Turner | .... | Retirement Home Assassin |
| Emily Kuroda | .... | Mrs. Chan |
| Joe Chrest | .... | Retirement Home Detective |
| Justine Wachsberger | .... | Nurse Mary |
| Tara Yelland | .... | Wilkes' Secretary |
| Ernest Borgnine | .... | Henry, The Records Keeper |
| Jefferson Brown | .... | Fred |
| John Malkovich | .... | Marvin Boggs |
| Audrey Wasilewski | .... | Businesswoman |
| James Remar | .... | Gabriel Singer |
| Dmitry Chepovetsky | .... | Surveillance Tech |
| Matthew Olver | .... | Surveillance Tech |
| Brian Cox | .... | Ivan Simanov |
| Jason Weinberg | .... | Lead CIA Tactical Officer |
| Tone DeSantis | .... | Security Chief |
| Greg Bryk | .... | Firefighter |
| Helen Mirren | .... | Victoria |
| Heidi Von Palleske | .... | Woman Neighbor |
| Richard Dreyfuss | .... | Alexander Dunning |
| Neil Whitely | .... | FBI Commander |
| Robert Morse | .... | Interrogator |
| Joshua Peace | .... | Interrogation Surveillance Tech |
| Michelle Nolden | .... | Michelle Cooper |
| Jake Goodman | .... | Cooper's Son |
| Tess Goodman | .... | Cooper's Daughter |
| Desiree Beausoleil | .... | Security Woman |
| Laura De Carteret | .... | Fundraiser Greeter |
| Jonathan Lloyd Walker | .... | Agent Burbacher |
| Julian McMahon | .... | Robert Stanton |
| Murray McRae | .... | Intro Speaker |
| Cindy Dukoff | .... | Banquet Guest |
| Thomas Mitchell | .... | Lone Agent |
| Bernadette Couture | .... | Agent |
| Chavis Brown | .... | Agent |
| Aaron Khon | .... | Agent |
| George Kash | .... | Band Member |
| John Marmora | .... | Band Member |
| Ron Johnston | .... | Band Member |
| John McLeod | .... | Band Member |
| Steve McDade | .... | Band Member |
| Bob DeAngelis | .... | Band Member |
| Bob Reeves | .... | Band Member |
| Leo Sullivan | .... | Band Member |
| Mark Ferguson | .... | Band Member |
| Anthony Marmora | .... | Band Member |
| Lenny Solomon | .... | Band Member |
| Valerie Winn | .... | Band Member |
| D'Arcy Allen | .... | New Orleans Police Officer (uncredited) |
| Annette Denise Bass | .... | Train Station Business Traveler (uncredited) |
| Brooke Bezick | .... | Bus station patron (uncredited) |
| Charlotte Biggs | .... | Train Station Passenger (uncredited) |
| Benjamin Blankenship | .... | Meldova Solider (uncredited) |
| Felder Charbonnet | .... | Paramedic (uncredited) |
| Joseph Cintron | .... | CIA Agent (uncredited) |
| Jamie Ferenczi | .... | Pension Office Cubical Worker (uncredited) |
| David Fultz | .... | Pedestrian (uncredited) |
| Emily D. Haley | .... | Onlooker (uncredited) |
| Gene Kevin Hames, jr. | .... | Soldier (uncredited) |
| Randy Herman | .... | Suite (uncredited) |
| Anthony Mark Johnson | .... | New Orleans Police Officer (uncredited) |
| Paul Kendall | .... | Secret Service (uncredited) |
| John C. Klein | .... | Onlooker (uncredited) |
| Jameson Kraemer | .... | CIA Doctor (uncredited) |
| Laurie Lee | .... | Train Station Traveler (uncredited) |
| Christopher Maddison | .... | Russian Guard (uncredited) |
| Tadhg McMahon | .... | CIA Tactical Officer (uncredited) |
| Ritchie Montgomery | .... | Pharmacist (uncredited) |
| Jay Oliver | .... | Resident at St Vincents (uncredited) |
| Johnny Otto | .... | Detective (uncredited) |
| B. J. Parker | .... | Police Officer (uncredited) |
| Michael Patrick Rogers | .... | Russian Soldier (uncredited) |
| Dan Shea | .... | Secret Service Agent (uncredited) |
| Adam Sibley | .... | Russian soldier (uncredited) |
| Lawanda Smith | .... | Train Station Traveler (uncredited) |
| Terry Lee Smith | .... | Pedestrian (uncredited) |
| James Lesley Taylor | .... | Train Station Traveler (uncredited) |
| Nancy E. L. Ward | .... | Sarah's Supervisor (uncredited) |