| Woody Harrelson | .... | Mickey Knox |
| Juliette Lewis | .... | Mallory Knox |
| Tom Sizemore | .... | Det. Jack Scagnetti |
| Rodney Dangerfield | .... | Ed Wilson, Mallory's Dad |
| Everett Quinton | .... | Deputy Warden Wurlitzer |
| Jared Harris | .... | London Boy |
| Pruitt Taylor Vince | .... | Deputy Warden Kavanaugh |
| Edie McClurg | .... | Mallory's Mom |
| Russell Means | .... | Old Indian |
| Lanny Flaherty | .... | Earl |
| O-Lan Jones | .... | Mabel |
| Robert Downey, jr. | .... | Wayne Gale |
| Richard Lineback | .... | Sonny |
| Kirk Baltz | .... | Roger |
| Ed White | .... | Pinball Cowboy |
| Terrylene | .... | Julie |
| Maria Pitillo | .... | Deborah |
| Josh Richman | .... | Soundman |
| Sean Stone | .... | Kevin |
| Melinda Renna | .... | Antonia Chavez |
| Jerry Gardner | .... | Work Boss #1 |
| Jack Caffrey | .... | Work Boss #2 |
| Leon Skyhorse Thomas | .... | Work Boss #3 |
| Corinna Everson | .... | TV Mallory |
| Dale Dye | .... | Dale Wrigley |
| Eddy 'Doogie' Conna | .... | Gerald Nash |
| Evan Handler | .... | David |
| Matthew Faber | .... | Kid #1 |
| Jamie Harrold | .... | Kid #2 |
| Jake Beecham | .... | Kid #3 |
| Saemi Nakamura | .... | Japanese Girl #1 / Japanese Reporter |
| Seiko Yoshida | .... | Japanese Girl #2 |
| Katharine McQueen | .... | London Girl |
| Salvator Xuereb | .... | French Boy #1 |
| Natalie Karp | .... | French Girl |
| Emmanuel Xuereb | .... | French Boy #2 |
| Balthazar Getty | .... | Gas Station Attendant |
| Jessie Rutkowski | .... | Young Girl |
| Sally Jackson | .... | Mickey's Mom |
| Phil Neilson | .... | Mickey's Dad |
| Brian Barker | .... | Young Mickey |
| Corinna Laszlo | .... | Emily, Hostage in Motel |
| Red West | .... | Cowboy Sheriff |
| Gerry Runnels | .... | Indian Cop |
| Jeremiah Bitsui | .... | Young Indian Boy |
| Lorraine Farris | .... | Pinky |
| Tommy Lee Jones | .... | Warden Dwight McClusky |
| Glen Chin | .... | Druggist |
| Steven Wright | .... | Dr. Emil Reingold |
| Peter Crombie | .... | Intense Cop |
| John M. Watson Sr. | .... | Black Inmate |
| Joe Grifasi | .... | Deputy Sheriff Duncan Homolka |
| Douglas Crosby | .... | Mallory's Guard #1 |
| Carl Ciarfalio | .... | Mallory's Guard #2 |
| Marshall Bell | .... | Deputy #1 |
| Carol-Renee Modrall | .... | Short-Order Cook |
| Jim Carrane | .... | Smithy |
| Bob Swan | .... | Deputy Napalatoni |
| Louis Lombardi | .... | Deputy Sparky |
| Robert Jordan | .... | WGN Newscaster |
| John Busse | .... | Reporter (uncredited) |
| Hank Corwin | .... | Headless Figure / Mickey's Dad Demon (uncredited) |
| Paul Dillon | .... | Prison Inmate Who Breaks TV (uncredited) |
| Herb Gains | .... | Wayne Gale's assistant (uncredited) |
| James Gammon | .... | Redneck's Buddy in the Diner (uncredited) |
| Jennifer Say Gan | .... | Asian Reporter (uncredited) |
| Jane Hamsher | .... | Female Demon (uncredited) |
| Mark Harmon | .... | Mickey Knox in Wayne Gale's Reconstructi (uncredited) |
| Arliss Howard | .... | Owen Traft, Mickey & Mallory's Guardian (uncredited) |
| Kathy Long | .... | Female deputy kicking Mickey (uncredited) |
| Robert Marshall | .... | Prison Guard (uncredited) |
| Don Murphy | .... | Prison Guard (uncredited) |
| Robyn Reede | .... | Lady Cop (uncredited) |
| Chris Renna | .... | Prisoner with Swastika Tattoo on Forehea (uncredited) |
| Jack Rooney | .... | Prison Inmate (uncredited) |
| Richard Rutowski | .... | Prisoner with Mustache (uncredited) |
| Keith Schrader | .... | Press Member (uncredited) |
| Kent Shelton | .... | Prison Snitch (Barber's Chair) (uncredited) |
| Michael Thomas | .... | Victim (uncredited) |
| Kevin Watson | .... | Spirit (uncredited) |