| Tom Cruise | .... | Reacher |
| Rosamund Pike | .... | Helen |
| Richard Jenkins | .... | Rodin |
| David Oyelowo | .... | Emerson |
| Werner Herzog | .... | The Zec |
| Jai Courtney | .... | Charlie |
| Vladimir Sizov | .... | Vlad |
| Joseph Sikora | .... | Barr |
| Michael Raymond-James | .... | Linsky |
| Alexia Fast | .... | Sandy |
| Josh Helman | .... | Jeb |
| Robert Duvall | .... | Cash |
| James Martin Kelly | .... | Rob Farrior |
| Dylan Kussman | .... | Gary |
| Denver Milord | .... | Punk |
| Susan Angelo | .... | Oline Archer |
| Julia Yorks | .... | Chrissie Farrior |
| Nicole Forester | .... | Nancy Holt |
| Delilah Picart | .... | Rita Coronado |
| Joe Coyle | .... | Darren Sawyer |
| Alicia Murton | .... | Mrs. Sawyer |
| Peter Gannon | .... | Mr. Archer |
| David Whalen | .... | Mr. Holt |
| Tristan Elma | .... | Marcos Coronado |
| Sophie Guest | .... | Little Girl |
| Michael Minor | .... | Eyewitness |
| Scott Martin | .... | Wesley |
| CJ Ramirez | .... | Secretary |
| Teri Clark Linden | .... | Night Manager |
| Jarid Faubel | .... | Man on Bus |
| Sara Lindsey | .... | Woman on Bus |
| Jace Jeanes | .... | Zec's Thug |
| Andrei Runtso | .... | Zec's Thug |
| Efka Kvaraciejus | .... | Zec's Thug |
| Lee Child | .... | Desk Sergeant |
| Tommy Lafitte | .... | Man with Ballcap |
| Kristen Dalton | .... | Mindy |
| Jordan Trovillion | .... | Goodwill Cashier |
| Annie Kitral | .... | Pawn Shop Cashier |
| Lissy Gulick | .... | Diner Waitress |
| Catherine Albers | .... | Jeb's Mom |
| Larissa Emanuele | .... | Sportsbar Waitress |
| Jason McCune | .... | Construction Foreman |
| Shane Callahan | .... | SWAT Guy |
| Joshua Elijah Reese | .... | SWAT Guy |
| Nathan Hollabaugh | .... | Cop |
| Christopher Stadulis | .... | Cop |
| Tony Amen | .... | Passenger on Bus (uncredited) |
| Diedra Arthur-O'Ree | .... | Police Officer (uncredited) |
| Tiffany Bell | .... | Cyclist (uncredited) |
| J Bizel | .... | Matt (uncredited) |
| Todd Bobenrieth | .... | Traveller (uncredited) |
| Ryan C. Bogdewic | .... | News Crewman (uncredited) |
| Nathan Bohatch | .... | Bus Passenger (uncredited) |
| Alonna Breisch | .... | Bus Passenger (uncredited) |
| Lonell R. Childred | .... | News10 Reporter (uncredited) |
| Tyler Courtad | .... | Bartender (uncredited) |
| Mark Falvo | .... | Journalist / By-Stander (uncredited) |
| Susan Feldbusch | .... | Office Worker (uncredited) |
| Tammy Felice | .... | Anne Yanni (uncredited) |
| Joe Fishel | .... | SWAT (uncredited) |
| Jim Fitzgerald | .... | Pittsburgh Police Officer (uncredited) |
| Vito Grassi | .... | Riverwalk Civilian (uncredited) |
| John W. Iwanonkiw | .... | Pittsburgh Police Officer (uncredited) |
| Joanne Jeffers | .... | Woman on Walkway / Onlooker (uncredited) |
| Al Kandrak | .... | Bus Passenger (uncredited) |
| William Kania | .... | Crime Scene Pedestrian (uncredited) |
| Tiffany Kemp | .... | Crime Scene Pedestrian (uncredited) |
| Sharyn Kmieciak | .... | Woman on Walkway / Onlooker (uncredited) |
| Wayne Leya | .... | Bus Passenger (uncredited) |
| Robert Liscio | .... | Man in Bar (uncredited) |
| Scott Lockhart | .... | Police Officer (uncredited) |
| Jeremy Long | .... | Man at Bus Station (uncredited) |
| Laurie Mann | .... | Knitting Lady on Bus (uncredited) |
| Frank McAleavey | .... | Medical Examiner (uncredited) |
| David Dale McCue | .... | Pittsburgh SWAT Officer (uncredited) |
| Kyle McGrath | .... | Man on Bus (uncredited) |
| Tiffany Sander McKenzie | .... | Riverwalk Civilian (uncredited) |
| F. Robert McMurray | .... | Onlooker (uncredited) |
| Michael Anthony Miller | .... | Medic (uncredited) |
| Molly Miller | .... | Lawyer (uncredited) |
| Jeremy Moon | .... | Thug (uncredited) |
| Amy Morse | .... | Bitter Woman (uncredited) |
| Paul Nandzik | .... | Pedestrian (uncredited) |
| Phil Nardozzi | .... | On Looker (uncredited) |
| Jackson Nunn | .... | Passenger / Bar Guy (uncredited) |
| Joe Pawlenko | .... | Refugee (uncredited) |
| Dave Petti | .... | Janitor (uncredited) |
| Edward Pfeifer | .... | Crime Scene Crowd (uncredited) |
| Ron Pucillo | .... | Detective (uncredited) |
| James Quinn | .... | Onlooker (uncredited) |
| Wesley Ray | .... | Bar Patron (uncredited) |
| Brent Reichert | .... | Doctor (uncredited) |
| Alexander Rhodes | .... | Suspicious Onlooker (uncredited) |
| Mike Ruchkin | .... | Onlooker (uncredited) |
| Jason Sabatasse | .... | Bus Terminal Bystander (uncredited) |
| Mike Stern | .... | Jewelry Clerk (uncredited) |
| Mike Walker | .... | Pittsburgh Police Officer (uncredited) |
| James Werley | .... | Diner Patron (uncredited) |
| Nickolas Wiegand | .... | Passenger (uncredited) |