| Mark Wahlberg | .... | Bob Lee Swagger |
| Michael Peņa | .... | Nick Memphis |
| Danny Glover | .... | Colonel Isaac Johnson |
| Kate Mara | .... | Sarah Fenn |
| Elias Koteas | .... | Jack Payne |
| Rhona Mitra | .... | Alourdes Galindo |
| Jonathan Walker | .... | Louis Dobbler |
| Justin Louis | .... | Howard Purnell |
| Tate Donovan | .... | Russ Turner |
| Rade Sherbedgia | .... | Michael Sandor |
| A. C. Peterson | .... | Officer Stanley Timmons |
| Ned Beatty | .... | Senator Charles F. Meachum |
| Lane Garrison | .... | Donnie Fenn |
| Zak Santiago | .... | Senior Agent |
| Michael-Ann Connor | .... | Junior Agent |
| Shawn Reis | .... | Underling |
| Brian Markinson | .... | Attorney General Russert |
| Michael St. John Smith | .... | FBI Director Brandt |
| Dean Monroe McKenzie | .... | Archbishop Desmond Mutumbo |
| Tom Butler | .... | President |
| Adrian Hughes | .... | Ben Davis |
| Darrin Massey | .... | Frank Russo |
| Mackenzie Gray | .... | Dave Simmons |
| Levon Helm | .... | Mr. Rate |
| Rebecca Toolan | .... | Mrs. Rate |
| Trish Allen | .... | Katy |
| James Wettengl | .... | Diver |
| John Tench | .... | Motel Owner |
| David Bloom | .... | Meachum's Valet |
| Brad Kelly | .... | Sorenson |
| David Neale | .... | Spook |
| Susan Barnett | .... | TV News Anchor #1 |
| Ukee Washington | .... | TV News Anchor #2 |
| Dagmar Midcap | .... | TV News Anchor #3 |
| Darrin Maharaj | .... | TV News Anchor #4 |
| Anthony McCrae | .... | Jefe |
| Mike Dopud | .... | Lead Mercenary |
| Chic Gibson | .... | Mayor of Philadelphia |
| Danny Hernandez | .... | K-9 Cop #1 |
| Jonathan Eusabio | .... | K-9 Cop #2 |
| Vale Anoai | .... | Woman in Crowd during Assassination |
| Alexander Emmert | .... | Agent #1 |
| Joe Barlam | .... | Pedestrian (uncredited) |
| Ernest E. Brown | .... | FBI Agent (uncredited) |
| Sharon Carpenter-Rose | .... | Presidential Speech Spectator (uncredited) |
| Alice Chamberlain | .... | Assignation Attempt Crowd (uncredited) |
| Karen Chamberlain | .... | Assignation Attempt Crowd (uncredited) |
| Damien Colletti | .... | College Student (uncredited) |
| Holly Eglinton | .... | Girl (uncredited) |
| Liam Ferguson | .... | Businessman (uncredited) |
| Patrick Ferguson | .... | Pedestrian (uncredited) |
| Tammy Gillis | .... | Waitress (uncredited) |
| Lauren Glazier | .... | Student (uncredited) |
| Thomas M. Hagen | .... | Pedestrian (uncredited) |
| Richard Jollymore | .... | Police Officer (uncredited) |
| Michael Wingate Jones | .... | Secret Service Agent (uncredited) |
| Michael Wingate Jones | .... | Driver (uncredited) |
| Fred Keating | .... | Winston Chuchill (uncredited) |
| William James Kelly | .... | Assassination Witness (uncredited) |
| Lawrence Laravela | .... | FBI Agent (uncredited) |
| Roberto Lombardi | .... | Assassination Witness (uncredited) |
| Steve Lord | .... | FBI Sniper (uncredited) |
| Mac McDonald | .... | Police Captain (uncredited) |
| Peter Mason | .... | Guitar Playing Pedestrian (uncredited) |
| Melissa McCarthy | .... | Night store clerk (uncredited) |
| Laurence Mullaney | .... | CIA Agent (uncredited) |
| Ken Myers | .... | Flag Waver (uncredited) |
| Ken Myers | .... | Grocery Man (uncredited) |
| Manny Oliverez | .... | Businessman (uncredited) |
| Henry Penzi | .... | Train conductor (uncredited) |
| Lil Rhee | .... | DC Resident (uncredited) |
| Vincent Riviezzo | .... | Phila Cop (uncredited) |
| Kurt Runkle | .... | Secret Service Agent (uncredited) |
| Roger Sands | .... | Assassination Witness (uncredited) |
| Chuck Schanamann | .... | Assassination Witness (uncredited) |
| David Adam Smith | .... | Businessman (uncredited) |
| Eugene Smith | .... | Assassination Witness (uncredited) |
| Patrick Michael Strange | .... | FBI Agent (uncredited) |
| Patrick Michael Strange | .... | DC Bike Cop (uncredited) |
| Patrick Michael Strange | .... | Businessman (uncredited) |
| Ian Thompson | .... | Motorcycle Cop (uncredited) |
| Frank Traynor | .... | Pedestrian (uncredited) |
| Sean Traynor | .... | Pedestrian (uncredited) |
| Dan Van Wert | .... | FBI Agent (uncredited) |
| Kimberly Villanova | .... | Witness (uncredited) |
| Torell Vinson | .... | Pedestrian (uncredited) |
| Jamal Weathers | .... | Car Wash Attendant (uncredited) |
| Don Whatley | .... | FBI Agent (uncredited) |
| Mike Wilson | .... | Sniper (uncredited) |
| Mike Wilson | .... | F.B.I. Agent (uncredited) |