 | Tobey Maguire | .... | Spider-Man / Peter Parker |
| Willem Dafoe | .... | Green Goblin / Norman Osborn |
| Kirsten Dunst | .... | Mary Jane Watson |
| James Franco | .... | Harry Osborn |
| Cliff Robertson | .... | Ben Parker |
| Rosemary Harris | .... | May Parker |
| J. K. Simmons | .... | J. Jonah Jameson |
| Joe Manganiello | .... | Flash Thompson |
| Gerry Becker | .... | Maximilian Fargas |
| Bill Nunn | .... | Joseph 'Robbie' Robertson |
| Jack Betts | .... | Henry Balkan |
| Stanley Anderson | .... | General Slocum |
| Ron Perkins | .... | Dr. Mendell Stromm |
| Michael Papajohn | .... | Carjacker |
| K. K. Dodds | .... | Simkins |
| Ted Raimi | .... | Hoffman |
| Bruce Campbell | .... | Ring Announcer |
| Elizabeth Banks | .... | Betty Brant |
| John Paxton | .... | Houseman |
| Tim deZarn | .... | Philip Watson |
| Taylor Gilbert | .... | Madeline Watson |
| Randy Savage | .... | Bone Saw McGraw |
| Larry Joshua | .... | Wrestling Promoter |
| Timothy Patrick Quill | .... | Wrestling Arena Guard |
| Lisa Danielle | .... | Bone-ette |
| Natalie T. Yeo | .... | Bone-ette |
| Erica D. Porter | .... | Bone-ette |
| Kristen Davidson | .... | Bone-ette |
| Jason Padgett | .... | Flash's Crony |
| Shan Omar Huey | .... | Teacher |
| Sally Levi | .... | Girl on Bus |
| Evan Arnold | .... | Doctor |
| Jill Sayre | .... | Nurse |
| Jim Ward | .... | Project Coordinator |
| David Holcomb | .... | Test Pilot |
| Octavia Spencer | .... | Check-In Girl |
| Brad Grunberg | .... | Heckler |
| Shane Habberstad | .... | Little Billy |
| Deborah Wakeham | .... | Billy's Mom |
| Rachael Bruce | .... | Times Square Child |
| Mackenzie Bryce | .... | Times Square Child |
| Julia Barry | .... | Times Square Child |
| Macy Gray | .... | Herself |
| Myk Watford | .... | Cop at Fire |
| William Calvert | .... | Fireman |
| Sylva Kelegian | .... | Mother at Fire |
| Kristen Marie Holly | .... | Young Lady at Fire |
| Ajay Mehta | .... | Cabbie |
| Peter Appel | .... | Cabbie |
| Scott Spiegel | .... | Marine Cop |
| Matt Smith | .... | Cop at Carjacking |
| Sara Ramirez | .... | Cop at Carjacking |
| Lucy Lawless | .... | Punk Rock Girl |
| Jayce Bartok | .... | Subway Guitarist |
| Maribel Gonzalez | .... | Lady Dogwalker |
| Amy Bouril | .... | Office Lady |
| Joseph D'Onofrio | .... | Opinionated Cop |
| Jim Norton | .... | Surly Truck Driver |
| Corey Mendell Parker | .... | Chaperone in Tram |
| Ashley Louise Edner | .... | Girl in Tram |
| William Joseph Firth | .... | Boy in Tram |
| Alex Black | .... | Boy in Tram |
| Laura Gray | .... | Tram Group Mother |
| Joe Virzi | .... | New Yorker on Bridge |
| Michael Edward Thomas | .... | New Yorker on Bridge |
| Jeanie Fox | .... | New Yorker on Bridge |
| Robert Kerman | .... | Tugboat Captain |
| Ari Averbach | .... | Dancer (uncredited) |
| Joni Avery | .... | Cop (uncredited) |
| Rick Avery | .... | Cop (uncredited) |
| Margaret Baker | .... | Punk #2 (uncredited) |
| Amy Beth Bennett | .... | Jewelry Thief #2 (uncredited) |
| Brian Bennett | .... | Doorman (uncredited) |
| Camille Bennett | .... | High School Student (uncredited) |
| Andy Bray | .... | Boy carrying tray in Cafeteria (uncredited) |
| Jophery C. Brown | .... | Chef (uncredited) |
| Jacob Chambers | .... | Cop (uncredited) |
| Jillian Clare | .... | Crying Girl in Tram (uncredited) |
| Chris Coppola | .... | Kyle (uncredited) |
| Cody Cundiff | .... | World Unity Day attendee (uncredited) |
| Una Damon | .... | Lab Tour Guide (uncredited) |
| Chandra De Alessandro | .... | Cop (uncredited) |
| Mark De Alessandro | .... | Cop (uncredited) |
| Michael Patrick Dobkins | .... | Wrestiling Fan (uncredited) |
| Patrick Coleman Duncan | .... | Oscorp Lab Technician (uncredited) |
| Marcus Edward | .... | Screaming Fan at Wrestling Match (uncredited) |
| Peter Genovese | .... | Fleeing World Unity Day Patron (uncredited) |
| Marcus Gorman | .... | Man in Street (uncredited) |
| Al Goto | .... | Cop (uncredited) |
| Juan M. Guerra | .... | City guy (uncredited) |
| Randy Hall | .... | Cop (uncredited) |
| Jesse Heiman | .... | Spectator at the scholl's fight. (uncredited) |
| Tia Dionne Hodge | .... | Uptown Woman (uncredited) |
| Kevin Jackson | .... | Bellman (uncredited) |
| Loren Janes | .... | Board of Directors Member (uncredited) |
| Andray Johnson | .... | Balkan's Aide (uncredited) |
| Claudia Katz | .... | Robbie's Assistant (uncredited) |
| Erik Kleven | .... | Chef (uncredited) |
| Stan Lee | .... | Man in Fair (uncredited) |
| Pete Macnamara | .... | Pentagon Officer (uncredited) |
| Joy Michelle Moore | .... | World's Fair mom (uncredited) |
| Justin Neill | .... | Flash's Crony (uncredited) |
| Philip Ng | .... | Diamond District Attendee (uncredited) |
| Debra Orenstein | .... | Doctor (uncredited) |
| Gary Otto | .... | New Yorker (uncredited) |
| Leroy Patterson | .... | World Unity Festival Attendant (uncredited) |
| Lance Polland | .... | Bonesaw Fan (uncredited) |
| January Pugh | .... | Mary Jane's Friend (uncredited) |
| Sumner Redstone | .... | Oscorp Board Member (uncredited) |
| Scott L. Schwartz | .... | Screaming Wrestler (uncredited) |
| Robair Sims | .... | Bellman (uncredited) |
| Richard Stephens | .... | Man on Brooklyn Bridge (uncredited) |
| Tammi Sutton | .... | Street Vendor (uncredited) |
| Lindsay Thompson | .... | Mary Jane's Friend (uncredited) |
| Lou Torres | .... | Enrique (uncredited) |
| Brigid Turner | .... | Featured Hot Girl (uncredited) |
| Benny Urquidez | .... | Mugger (uncredited) |
| Sean Valla | .... | Boat Light Man (uncredited) |
| Derek C. Wallace | .... | Homeless Man (uncredited) |
| John Wojnowski III | .... | Man in Street (uncredited) |
Spider-Man
USA
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