| Kevin Spacey | .... | Francis Underwood |
| Robin Wright | .... | Claire Underwood |
| Michael Kelly | .... | Doug Stamper |
| Derek Cecil | .... | Seth Grayson |
| Elizabeth Marvel | .... | Heather Dunbar |
| Neve Campbell | .... | Leann Harvey |
| Nathan Darrow | .... | Edward Meechum |
| Sebastian Arcelus | .... | Lucas Goodwin |
| Jayne Atkinson | .... | Catherine Durant |
| Reed Birney | .... | VP Donald Blythe |
| Eisa Davis | .... | Cynthia Driscoll |
| Ellen Burstyn | .... | Elizabeth Hale |
| David Pittu | .... | Dr. Saxon |
| Ellen Harvey | .... | Martha Wilson |
| Mercedes Herrero | .... | Director of National Intelligence |
| John Rue | .... | CIA Director |
| Julian Gamble | .... | Chairman of Joint Chiefs |
| Charles Gibson | .... | Charles Gibson |
| Wolf Blitzer | .... | Wolf Blitzer |
| Leonid Citer | .... | Igor Milkin |
| Lancer Shull | .... | CIA Agent |
| Dustin Lewis | .... | Aide |
| Rich Barlow | .... | Moderator |
| Stacy Rabon | .... | Middle Aged Woman |
| Brian Hatch | .... | Young Man |
| Herrari Hamilton | .... | Young Woman |
| Lindsley Register | .... | Protester |
| Erica Frene | .... | Seth's Secretary |
| Daryl Ray Carliles | .... | Seth's Staffer |
| Corey Maher | .... | Secret Service Agent |
| Kenneth Israel | .... | Secret Service Agent |
| Draaco Aventura | .... | WH Press Corps |
| Valerie Boyd | .... | College Student |
| Loretta Burnette | .... | Protestor |
| Stephanie Cookie Carson | .... | Protestor |
| Gregory Divers | .... | White House Press Corps |
| John-Patrick Driscoll | .... | Dunbar's Comm Director |
| Lindsay Dyan Epp | .... | White House Press |
| Valerie Grace | .... | White House Press Photographer |
| Johnna Leary | .... | College Student |
| Cathleen Trigg | .... | Anchor |
| Towanda Underdue | .... | Secretary of education |
| Marla Aaron Wapner | .... | WH Press Corp |
| Gary Ayash | .... | White House Press Corp Reporter-Press Room (uncredited) |
| Frances A. Cheever | .... | Trauma Doctor (uncredited) |
| Justin Doescher | .... | Frank Underwood Security (uncredited) |
| Kerry Dutka | .... | Underwood Rally Support (uncredited) |
| Catherine Duvall | .... | College Student (uncredited) |
| Lamont Easter | .... | Underwood Secret Service (uncredited) |
| Mark Falvo | .... | White House Press Corps (uncredited) |
| Joe Fishel | .... | Video Camera Operator (uncredited) |
| Christopher Fleming | .... | College Student / Student Protester (uncredited) |
| Nick Grant | .... | Student Protester (uncredited) |
| Theophilus Griffin | .... | Underwood Supporter (uncredited) |
| Debbie Hartner | .... | Madelyn RN (uncredited) |
| Greg Lang | .... | Military Aide (uncredited) |
| Joseph Lisa | .... | College Student (uncredited) |
| Antoinette Montgomery | .... | White House Press Corps (uncredited) |
| Anita Moore | .... | Trauma Nurse (uncredited) |
| Mark Salas | .... | News Media (uncredited) |
| Eric Santamaria | .... | Underwood Supporter (uncredited) |
| Hillary Schenning | .... | Francis Supporter (uncredited) |