| Kevin Spacey | .... | Francis Underwood |
| Robin Wright | .... | Claire Underwood |
| Michael Kelly | .... | Doug Stamper |
| Mahershala Ali | .... | Remy Danton |
| Elizabeth Marvel | .... | Heather Dunbar |
| Derek Cecil | .... | Seth Grayson |
| Jimmi Simpson | .... | Gavin Orsay |
| Nathan Darrow | .... | Edward Meechum |
| Jayne Atkinson | .... | Catherine Durant |
| Rachel Brosnahan | .... | Rachel Posner |
| Mozhan Marnò | .... | Ayla Sayyad |
| Benito Martinez | .... | Hector Mendoza |
| Reed Birney | .... | VP Donald Blythe |
| Poorna Jagannathan | .... | Dr. Lanjawni |
| Kelly AuCoin | .... | Gary Stamper |
| Jonathan Hogan | .... | Justice Jacobs |
| Christina Bennett Lind | .... | Sharon |
| Sam Freed | .... | Paul Landry |
| Ari Melber | .... | Ari Melber |
| Perry Bacon Jr. | .... | Perry Bacon |
| Stephen Colbert | .... | Stephen Colbert |
| Neal Matarazzo | .... | Detective Pryor |
| Chris McKinney | .... | Detective Noland |
| Olivia Luccardi | .... | Escort |
| John Rue | .... | CIA Director |
| Mercedes Herrero | .... | National Security Advisor |
| Julian Gamble | .... | Chairman of Joint Chiefs |
| Robert Poletick | .... | Defense Secretary Davis |
| Jeffrey Voice | .... | Colonel |
| Andrea Leigh | .... | WH Secretary |
| William Thomas | .... | WH Reporter Greg |
| Julie Mun | .... | WH Reporter Sara |
| Tim Pabon | .... | WH Reporter Mark |
| Staci Dickerson | .... | WH Reporter Jess |
| Maceo Oliver | .... | ER Doctor |
| Adam Devine | .... | Photographer at Graveyard |
| Chrislene Bright | .... | White House Press Corp. |
| Michael Garvey | .... | Delegate |
| Joanna Gordon | .... | Reporter |
| Brittney Aleah | .... | White House Staffer / White House Financial Advisor (uncredited) |
| Gary Ayash | .... | White House Press Corp Reporter (uncredited) |
| Peter Chiamardas | .... | White House Press (uncredited) |
| Benjamin Cook | .... | Heather Dunbar's Son (uncredited) |
| James Davenjay | .... | White House Staff (uncredited) |
| Patricia DiZebba | .... | Nurse (uncredited) |
| Justin Doescher | .... | Frank Underwood Security (uncredited) |
| Catherine Duvall | .... | Reporter (uncredited) |
| Lamont Easter | .... | Underwood Secret Service (uncredited) |
| Lindsay Dyan Epp | .... | White House Press (uncredited) |
| Mark Falvo | .... | White House Press Corps (uncredited) |
| Mary-Alice Farina | .... | White House Press Corps (uncredited) |
| Liam Ferguson | .... | Press / Photographer (uncredited) |
| Dave Ferrier | .... | Videographer (uncredited) |
| Shawn Gonzalez | .... | White House Staff (uncredited) |
| Cynthia Kossally | .... | Nurse (uncredited) |
| Mark Vincent | .... | Tactical Secret Service (uncredited) |
| Marla Aaron Wapner | .... | WH Press Corp (uncredited) |