 | Tom Cruise | .... | Roy Miller |
| Cameron Diaz | .... | June Havens |
| Peter Sarsgaard | .... | Fitzgerald |
| Jordi Mollą | .... | Antonio |
| Viola Davis | .... | Director George |
| Paul Dano | .... | Simon Feck |
| Falk Hentschel | .... | Bernhard |
| Marc Blucas | .... | Rodney |
| Lennie Loftin | .... | Braces |
| Maggie Grace | .... | April Havens |
| Rich Manley | .... | Danny |
| Dale Dye | .... | Frank Jenkins |
| Celia Weston | .... | Molly |
| Gal Gadot | .... | Naomi |
| Jack A. O'Connell | .... | Wilmer |
| Trevor Loomis | .... | Eduardo |
| Nilaja Sun | .... | Allison |
| Tommy Nohilly | .... | Randy Mechanic |
| Taylor Treadwell | .... | Gate Agent |
| Christian Finnegan | .... | Ticket Agent |
| Nicholas Reese Art | .... | Kid at Airport |
| Brian Dykstra | .... | TSA Officer |
| Brian Tarantina | .... | Scrap Yard Man |
| Natasha Paczkowski | .... | Petra The Tailor |
| Jerrell Lee | .... | Fireman Paul |
| Matthew Lawler | .... | Passerby Agent |
| Ronn Surels | .... | Flight Attendant |
| Eric Robert Bradshaw Bennett | .... | 18 Wheeler Driver |
| Scott Wahle | .... | Newscaster |
| Sara Underwood | .... | Newscaster #2 |
| Helen L. Welsh | .... | Neighbor |
| King Orba | .... | Smuggler |
| Adam Gregor | .... | Train Cook |
| Mitch E. Bowan | .... | Medivac EMT |
| Gerald T. Carbajal | .... | Doctor In Hallway |
| Michael Enright | .... | Engineer |
| Charlie Alejandro | .... | Soldier at Airport (uncredited) |
| Carl Alleyne | .... | Groomsman (uncredited) |
| Brian Bradbury | .... | Restaurant Patron (uncredited) |
| Catherine Burt | .... | Waitress (uncredited) |
| Katelyn Cahill | .... | Bridesmaid (uncredited) |
| Desiree April Connolly | .... | Pedestrian / Commuter (uncredited) |
| Jeffrey Corazzini | .... | Automotive Technician (uncredited) |
| D. W. Cormier | .... | Airport Vendor (uncredited) |
| Holland Diaz | .... | Plane Agent (uncredited) |
| Sean Patrick Doherty | .... | State trooper (uncredited) |
| Paul Elicone | .... | Busboy (uncredited) |
| Susan Farese | .... | Woman in Airport Pub (uncredited) |
| Keith Fluker | .... | Agent (uncredited) |
| Hugo Garcia | .... | Bull Runner (uncredited) |
| Suzanne Gillies | .... | Airport Ticket Agent (uncredited) |
| Mark Hetherington | .... | Downtown Pedestrian (uncredited) |
| Frankie Imbergamo | .... | Restaurant Patron (uncredited) |
| Georgina Ransley | .... | Airport Girlfriend (uncredited) |
| Erica LaRose | .... | Dizzy Day (uncredited) |
| C. R. Marchi | .... | Restaurant Patron (uncredited) |
| Dan Marshall | .... | Restaurant Patron (uncredited) |
| Jeff Martineau | .... | U.S. Army Private (uncredited) |
| Robert Masiello | .... | Guest at grille (uncredited) |
| Erica McDermott | .... | Bridesmaid (uncredited) |
| Scott Neufville | .... | Bus Passenger (uncredited) |
| Greg Paul | .... | Airport Police / Fire / EMT (uncredited) |
| Michael Stavrinos | .... | Undercover Agent / GTO Chase Scene (uncredited) |
| Stream | .... | Witchita Airport Traveller (uncredited) |
| George J. Vezina | .... | Construction worker (uncredited) |
| Stephanie Worth | .... | Rodney's Girl (uncredited) |
Knight and Day
USA
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