| Max Grodénchik | .... | Himself |
| Andrew Robinson | .... | Himself |
| Armin Shimerman | .... | Himself |
| Nana Visitor | .... | Herself |
| Colm Meaney | .... | Himself |
| Jeffrey Combs | .... | Himself |
| Aron Eisenberg | .... | Himself |
| Rene Auberjonois | .... | Himself |
| Ira Steven Behr | .... | Himself |
| Alexander Siddig | .... | Himself |
| Casey Biggs | .... | Himself |
| Rick Berman | .... | Himself |
| Kerry McCluggage | .... | Himself |
| Terry Farrell | .... | Herself |
| Junie Lowry-Johnson | .... | Herself |
| Ron Surma | .... | Himself |
| Ian Spelling | .... | Himself |
| Terry J. Erdmann | .... | Himself |
| Jonathan West | .... | Himself |
| David Carson | .... | Himself |
| Marc Bernardin | .... | Himself |
| Penny Johnson Jerald | .... | Herself |
| Avery Brooks | .... | Himself |
| 'B.C. Cameron' | .... | Herself |
| David Livingston | .... | Himself |
| Robert Hewitt Wolfe | .... | Himself |
| Hans Beimler | .... | Himself |
| René Echevarria | .... | Himself |
| Ronald D. Moore | .... | Himself |
| Herman Zimmerman | .... | Himself |
| Denise Okuda | .... | Herself |
| Doug Drexler | .... | Himself |
| Michael Okuda | .... | Himself |
| Dan Curry | .... | Himself |
| Chase Masterson | .... | Herself |
| Cecily Adams | .... | Herself(archive footage) |
| 'Lou Race' | .... | Himself |
| Michael Dorn | .... | Himself |
| Wallace Shawn | .... | Himself |
| Marc Alaimo | .... | Himself |
| Michael Westmore | .... | Himself |
| Ben Robinson | .... | Himself |
| Michael Piller | .... | Himself(archive footage) |
| Lolita Fatjo | .... | Herself |
| John Putman | .... | Himself |
| James Darren | .... | Himself |
| Steve Oster | .... | Himself |
| Bill Mumy | .... | Himself |
| Dennis Madalone | .... | Himself |
| J. G. Hertzler | .... | Himself |
| Robert O'Reilly | .... | Himself |
| Cirroc Lofton | .... | Himself |
| 'Felecia Bell Rutkowski' | .... | Herself |
| Nicole de Boer | .... | Herself |
| Hana Hatae | .... | Herself |
| Larry Nemecek | .... | Himself |
| Jake Black | .... | Himself (uncredited) |
| Rosalind Chao | .... | Keiko O'Brien(archive footage) (uncredited) |
| John Colicos | .... | Kor(archive footage) (uncredited) |
| Louise Fletcher | .... | Winn Adami(archive footage) (uncredited) |
| Jonathan Frakes | .... | Commander William T. Riker(archive footage) (uncredited) |
| Mistress Harley | .... | Mistress Harley (uncredited) |
| Salome Jens | .... | Female Shapeshifter(archive footage) (uncredited) |
| Deborah Lacey | .... | Sarah Sisko(archive footage) (uncredited) |
| Leigh McCloskey | .... | Joran Belar(archive footage) (uncredited) |
| Randy Oglesby | .... | Silaran(archive footage) (uncredited) |
| Iggy Pop | .... | Yelgrun(archive footage) (uncredited) |
| William Shatner | .... | Kirk (archive footage) (uncredited, Stimme) |
| Mark Allen Shepherd | .... | Morn(archive footage) (uncredited) |
| Frank Owen Smith | .... | Curzon(archive footage) (uncredited) |
| Luke Snailham | .... | Himself (uncredited) |
| Brent Spiner | .... | Lt. Commander Data(archive footage) (uncredited) |
| Patrick Stewart | .... | Captain Jean-Luc Picard(archive footage) (uncredited) |
| Susanna Thompson | .... | Dr. Lenara Kahn(archive footage) (uncredited) |
| Donald Trump | .... | Himself(archive footage) (uncredited) |
| Clarence Williams III | .... | Omet'iklan(archive footage) (uncredited) |
| Harris Yulin | .... | Aamin Marritza(archive footage) (uncredited) |