| Eddie Redmayne | .... | Newt |
| Sam Redford | .... | Customs Official |
| Scott Goldman | .... | Customs Official (Stimme) |
| Tim Bentinck | .... | Witness |
| Tristan Tait | .... | Reporter |
| Colin Farrell | .... | Graves |
| Tom Clarke-Hill | .... | Photographer 2 |
| Matthew Sim | .... | Photographer 1 |
| Katherine Waterston | .... | Tina |
| Samantha Morton | .... | Mary Lou |
| Dan Fogler | .... | Jacob Kowalski |
| Ezra Miller | .... | Credence Barebone |
| Faith Wood-Blagrove | .... | Modesty Barebone |
| Jenn Murray | .... | Chastity Barebone |
| Cory Peterson | .... | Bank Employee |
| Lucie Pohl | .... | Secretary |
| Peter Breitmayer | .... | Mr. Bingley |
| Jake Samuels | .... | Bank Guard |
| Max Cazier | .... | Young Man |
| Dan Hedaya | .... | Red |
| Christy Meyer | .... | Guide - Inside Macusa |
| Carmen Ejogo | .... | Seraphina Picquery |
| Guy Paul | .... | Auror 2 |
| Andreea Paduraru | .... | Auror 9 |
| Walles Hamonde | .... | Auror 10 |
| Dominique Tipper | .... | Auror 1 |
| Kevin Guthrie | .... | Mr. Abernathy |
| Leo Heller | .... | Boy with Birthmark |
| Miles Roughley | .... | Poor Boy |
| Anne Wittman | .... | Housewife |
| Erick Hayden | .... | Policeman |
| Paul Birchard | .... | Hobo |
| Ronan Raftery | .... | Langdon Shaw |
| Tom Hodgkins | .... | Barker |
| Jon Voight | .... | Henry Shaw Sr. |
| Josh Cowdery | .... | Henry Shaw Jr. / Senator Shaw |
| Ellie Haddington | .... | Mrs. Esposito |
| Alison Sudol | .... | Queenie |
| Joseph Macnab | .... | Police Officer 1 |
| Bart Edwards | .... | Police Officer 2 |
| Todd Boyce | .... | Announcer |
| Martin Oelbermann | .... | Heinrich Eberstadt |
| Gemma Chan | .... | Madam Ya Zhou |
| Richard Clothier | .... | British Envoy |
| Christian Dixon | .... | Momolou Wotorson |
| Akin Gazi | .... | Auror 3 |
| Richard Hardisty | .... | Auror 4 |
| Elizabeth Moynihan | .... | Executioner 1 |
| Miquel Brown | .... | Executioner 2 |
| Wunmi Mosaku | .... | Beryl |
| Cristian Solimeno | .... | Executioner 3 |
| Matthew Wilson | .... | Sam the Obliviator |
| Brian F. Mulvey | .... | Watchman |
| Aretha Ayeh | .... | Singer - The Blind Pig Speakeasy |
| Emmi | .... | Singer - The Blind Pig Speakeasy |
| Ron Perlman | .... | Gnarlack |
| Nicholas McGaughey | .... | Australian Wizard |
| Sean Cronin | .... | Nearby Criminal |
| Zoë Kravitz | .... | Lestrange |
| Arinze Kene | .... | Auror 6 |
| Jane Perry | .... | Female Customer in Bakery |
| Johnny Depp | .... | Grindelwald |
| Abi Adeyemi | .... | International Royal Dignitary (uncredited) |
| Andrea Allan | .... | Gala Dinner Guest (uncredited) |
| Reid Anderson | .... | Auror (uncredited) |
| Gabriele Antonini | .... | Newspaper Boy (uncredited) |
| Aileen Archer | .... | Criminal (uncredited) |
| Robert-Anthony Artlett | .... | Upperclass Wizard (uncredited) |
| Stephanie Aspin | .... | Ruby (uncredited) |
| Lee Asquith-Coe | .... | Officer 247 (uncredited) |
| Lasco Atkins | .... | Pedestrian (uncredited) |
| Martin Atkinson | .... | Gala Dinner Guest (uncredited) |
| Alphonso Austin | .... | Boat Crew (uncredited) |
| Michael Barron | .... | New Yorker (uncredited) |
| Roy Beck | .... | Senator Shaw's Speechwriter (uncredited) |
| Marc Benanti | .... | Journalist (uncredited) |
| Nathan Benham | .... | Bank Guard (uncredited) |
| Paul Bergquist | .... | Gala Dinner Guest (uncredited) |
| Laura Bernardeschi | .... | Italian Tenant in New York (uncredited) |
| David J Biscoe | .... | Journalist (uncredited) |
| Mel Blakey | .... | Photographer (uncredited) |
| Lee Bolton | .... | Photographer (uncredited) |
| Annarie Boor | .... | New Yorker (uncredited) |
| Martin Bratanov | .... | New Yorker (uncredited) |
| Elizabeth Briand | .... | Gala Guest (uncredited) |
| Neil Broome | .... | Gala Dinner Guest (uncredited) |
| Greg Brummel | .... | New York Tenement (uncredited) |
| Chloe de Burgh | .... | Tenement Woman (uncredited) |
| Douglas Byrne | .... | Gala Guest (uncredited) |
| Fanny Carbonnel | .... | Mrs. Goldstein (uncredited) |
| Adam Chamberlain | .... | Store Worker (uncredited) |
| David Charles-Cully | .... | Gentleman (uncredited) |
| Stacey Clegg | .... | Gala Dinner Guest (uncredited) |
| Eric Coco | .... | Tenement (uncredited) |
| Bern Collaço | .... | Auror / Boat Passenger (uncredited) |
| Chloe Collingwood | .... | Taxi Passenger (uncredited) |
| Claire Cooper-King | .... | Gala Dinner Guest (uncredited) |
| Armin Coralic | .... | New Yorker (uncredited) |
| Carmen Cowell | .... | Tenement Woman (uncredited) |
| Silvia Crastan | .... | New Yorker (uncredited) |
| Tom Dab | .... | Factory Worker (uncredited) |
| Craig Davies | .... | New Yorker (uncredited) |
| Nick Davison | .... | Factory Worker (uncredited) |
| Michael Deighton | .... | Gala Dinner Guest (uncredited) |
| Paul Dewdney | .... | New York Journalist (uncredited) |
| Rudi Dharmalingam | .... | Ranjit (uncredited) |
| Joshua Diffley | .... | Young Husband (uncredited) |
| Nick Donald | .... | Bank Customer (uncredited) |
| Richard Douglas | .... | Gentleman (uncredited) |
| Henry Douthwaite | .... | Skender (uncredited) |
| Stephanie Eccles | .... | Gala Dinner Guest (uncredited) |
| Karl Farrer | .... | Banker (uncredited) |
| Dino Fazzani | .... | Factory Worker (uncredited) |
| Flor Ferraco | .... | Bank Client (uncredited) |
| Marketa Flynn | .... | New Yorker (uncredited) |
| Lobna Futers | .... | Witch (uncredited) |
| Michael Gabbitas | .... | Gala Guest (uncredited) |
| David Goodson | .... | Porter (uncredited) |
| Kirsty Grace | .... | Jazz Girl (uncredited) |
| Rudy Valentino Grant | .... | New York Street Sweeper (uncredited) |
| Charlene Griffith | .... | New Yorker (uncredited) |
| Guna Gultniece | .... | Immigrant (uncredited) |
| Robin Harvey | .... | Fundraiser Guest (uncredited) |
| Abigayle Honeywill | .... | Criminal (uncredited) |
| Luke Hope | .... | NYC Banker (uncredited) |
| Ruth Clarson | .... | New Yorker (uncredited) |
| Kornelia Horvath | .... | South American Passenger on Newt's Boat (uncredited) |
| Finley Howard | .... | Poor Boy (uncredited) |
| Ashley Hudson | .... | Young Gentleman (uncredited) |
| Alan Wyn Hughes | .... | Gala Photographer (uncredited) |
| Alex Jaep | .... | Pedestrian (uncredited) |
| Ian Jenkins | .... | High Society Gentleman (uncredited) |
| Patrick Carney Junior | .... | Gala Dinner Guest (uncredited) |
| Solomon Taiwo Justified | .... | Wizard (uncredited) |
| Lampros Kalfuntzos | .... | Male Passenger on Newt's Boat (uncredited) |
| Kath Kelly | .... | Gala Dinner Guest (uncredited) |
| Attila G. Kerekes | .... | New York Citizen (uncredited) |
| Simon Kerrison | .... | High Society Gentleman / Gala Guest (uncredited) |
| Denis Khoroshko | .... | Banker Smirnoff (uncredited) |
| Cristian Lazar | .... | New York Citizen (uncredited) |
| Adam Lazarus | .... | Wizard (uncredited) |
| Cole Leman | .... | Customs Officer (uncredited) |
| Jorge Leon Martinez | .... | Spaniard Ship Passenger (uncredited) |
| Mickey Lewis | .... | New Yorker (uncredited) |
| Adam Lezemore | .... | Gala Guest (uncredited) |
| Dom Lister | .... | Journalist (uncredited) |
| Keith Lomas | .... | New York Socialite (uncredited) |
| Paul Low-Hang | .... | Pentagram Nobleman (uncredited) |
| Jennie Luke | .... | Macusa Receptionist (uncredited) |
| Khristopher MacLeod | .... | Higher Class Gentleman (uncredited) |
| Joe Malone | .... | Young Wizard (uncredited) |
| Alan Mandel | .... | Mr. Goldstein (uncredited) |
| Simon Manley | .... | Tenement Dweller (uncredited) |
| Christine Marzano | .... | Exterminator (uncredited) |
| Pete Meads | .... | Factory Worker (uncredited) |
| Andy Mihalache | .... | Bank Customer (uncredited) |
| Arnold Montey | .... | Journalist (uncredited) |
| James M. L. Muller | .... | Newsroom Reporter (uncredited) |
| Paul A Munday | .... | Journalist (uncredited) |
| John Murray | .... | Blind Pig Criminal (uncredited) |
| Dennis O'Donnell | .... | Circus Escapologist (uncredited) |
| Yves O'Hara | .... | Gala Dinner Guest (uncredited) |
| Andrew G. Ogleby | .... | New York Factory Worker (uncredited) |
| Edd Osmond | .... | Creature Performer (uncredited) |
| Nick Owenford | .... | New York Gentleman (uncredited) |
| Sascha Panknin | .... | Upperclass Wizard (uncredited) |
| Andrew Parker | .... | Gangster at Bar (uncredited) |
| Rico Pass | .... | Boy - Various street scenes (uncredited) |
| Alan Peett | .... | Bank Begging Tramp (uncredited) |
| Gino Picciano | .... | Gangster (uncredited) |
| Richard Price | .... | Gala Guest (uncredited) |
| Olivia Quinn | .... | Aunt of the Bride (uncredited) |
| Paul Redfern | .... | Gala Guest (uncredited) |
| Jason Redshaw | .... | Higher Class Gentleman (uncredited) |
| Eddie Register | .... | Passerby (uncredited) |
| Alan Ridgwell | .... | Extra (uncredited) |
| Alexsandria Rothschild | .... | Gala Guest (uncredited) |
| Anthony J Sacco | .... | Gala Guest (uncredited) |
| Bernardo Santos | .... | Smart New Yorker (uncredited) |
| Dave Simon | .... | New York Socialite (uncredited) |
| David Soffe | .... | Gala Dinner Guest (uncredited) |
| Ryan Storey | .... | Waiter (uncredited) |
| Connor Sullivan | .... | Gala Guest (uncredited) |
| Camilla Talarowska | .... | New York Citizen (uncredited) |
| Fran Targ | .... | Pentagram Nobleman (uncredited) |
| Mitchell Thornton | .... | Gala Doorman and Waiter (uncredited) |
| Daniela Tlumacova | .... | Immigrant in New York City (uncredited) |
| Dan Trotter | .... | Street Vendor (uncredited) |
| Vassiliki Tzanakou | .... | Boat Passenger (uncredited) |
| Jack Uglow | .... | New York Citizen (uncredited) |
| Geeta Vij | .... | Auror (uncredited) |
| Mahala Wallace | .... | Tenement Woman (uncredited) |
| Morgan Walters | .... | Watchman (uncredited) |
| Dean Weir | .... | Bank Guard (uncredited) |
| Anick Wiget | .... | Criminal on 'Wanted' Poster (uncredited) |
| Kevin Winkley | .... | Gala Dinner Guest (uncredited) |
| Miroslav Zaruba | .... | Bank Guard (uncredited) |