| John Cusack | .... | Jackson Curtis |
| Amanda Peet | .... | Kate Curtis |
| Chiwetel Ejiofor | .... | Dr. Adrian Helmsley |
| Thandiwe Newton | .... | Dr. Laura Wilson |
| Oliver Platt | .... | Carl Anheuser |
| Tom McCarthy | .... | Gordon Silberman |
| Woody Harrelson | .... | Charlie Frost |
| Danny Glover | .... | President Thomas Wilson |
| Liam James | .... | Noah Curtis |
| Morgan Lily | .... | Lilly Curtis |
| Zlatko Buric | .... | Yuri Karpov |
| Beatrice Rosen | .... | Tamara |
| Alexandre Haussmann | .... | Alec Karpov |
| Philippe Haussmann | .... | Oleg Karpov |
| Johann Urb | .... | Sasha |
| John Billingsley | .... | Professor West |
| Chin Han | .... | Tenzin |
| Osric Chau | .... | Nima |
| Tseng Chang | .... | Grandfather Sonam |
| Lisa Lu | .... | Grandmother Sonam |
| Blu Mankuma | .... | Harry Helmsley |
| George Segal | .... | Tony Delgatto |
| Stephen McHattie | .... | Captain Michaels |
| Patrick Bauchau | .... | Roland Picard |
| Jimi Mistry | .... | Dr. Satnam Tsurutani |
| Ryan McDonald | .... | Scotty |
| Merrilyn Gann | .... | German Chancellor |
| Henry O | .... | Lama Rinpoche |
| Patrick Gilmore | .... | Ark Communications Officer |
| Dean Marshall | .... | Ark Communications Officer |
| Ron Selmour | .... | Ark Boarding Officer |
| Viv Leacock | .... | Ark Boarding Officer |
| Chris Boyd | .... | Ark Boarding Officer |
| Donna Yamamoto | .... | AF1 Science Officer |
| Doron Bell Jr. | .... | AF1 Science Officer |
| David Orth | .... | AF1 Lieutenant |
| Lyndall Grant | .... | Governor |
| Jason Diablo | .... | Ark Tech Officer |
| Ty Olsson | .... | AF1 Officer |
| Zinaid Memisevic | .... | President Sergey Makarenko |
| Vincent Cheng | .... | Chinese Colonel |
| Igor Morozov | .... | Russian Interpreter |
| BJ Harrison | .... | Woman Comforting Child |
| Dominic Zamprogna | .... | Paramedic |
| Karin Konoval | .... | Sally |
| Mary Gillis | .... | Jackson's Neighbor |
| Rick Tae | .... | Megaphone Officer |
| Parm Soor | .... | Saudi Prince |
| Gerard Plunkett | .... | Isaacs |
| Paul Tryl | .... | Zultan |
| Andrei Kovski | .... | Zultan's Trainer |
| Val Cole | .... | News Reporter - Tikal |
| Eve Harlow | .... | Cashier |
| Sean Tyson | .... | Interrogating Officer |
| Leonard Tenisci | .... | Italian Prime Minister |
| Michael Buffer | .... | Boxing Announcer |
| Daren A. Herbert | .... | Ship Waiter |
| Craig Stanghetta | .... | Vegas Rescue Worker |
| Mateen Devji | .... | Ajit - age 5 |
| Qayam Devji | .... | Ajit - age 9 |
| Jody Thompson | .... | CNN Anchor |
| Tanya Champoux | .... | Mrs. Birnbaum |
| Frank C. Turner | .... | Preacher |
| Kinua McWatt | .... | Yoko Delgatto |
| Laara Sadiq | .... | British Newscaster |
| Gillian Barber | .... | Cruise Ship Lady |
| Candus Churchill | .... | Cruise Ship Lady |
| Beverley Elliott | .... | Cruise Ship Lady |
| Agam Darshi | .... | Aparna S. Tsurutani |
| Raj Lal | .... | Gurdeep |
| Pesi Daruwalla | .... | Dr. Lokesh |
| Jacob Blair | .... | AF1 Steward |
| Jay Williams | .... | AF1 Steward |
| Scott Miller | .... | Arc Naval Officer |
| Anna Mae Wills | .... | Officer Tay |
| John Stewart | .... | Pilot |
| Ryan Cook | .... | Surfer |
| Brandon Haas | .... | Surfer |
| Eddie Hassell | .... | Surfer |
| Betty Phillips | .... | Elderly Driver |
| Georgina Hegedos | .... | Elderly Driver |
| Luis Javier | .... | Vegas Tow Truck Driver |
| Dean Redman | .... | Vegas Fireman |
| Gordon Lai | .... | Security Commander |
| Mark Docherty | .... | Field Reporter - Tikal |
| Mark Oliver | .... | Fundraiser Security |
| Andrew Moxham | .... | Policeman |
| Alexandra Castillo | .... | Paris Reporter |
| Farouk A. Afify | .... | Saudi Senior Security |
| Shaun Wilson | .... | US Army Worker |
| Leo Chiang | .... | Chinese Soldier |
| Elizabeth Richard | .... | Queen Elizabeth |
| Kyle Riefsnyder | .... | Cho Ming Platform Officer |
| John Mee | .... | Angry Billionaire |
| George Trochta | .... | American Ark Steward |
| Geoff Gustafson | .... | Ark Bridge Crew |
| Alex Zahara | .... | Mr. Anton |
| Jase Anthony Griffith | .... | Ark Bridge Crew |
| Jill Morrison | .... | Ark Bridge Crew |
| Thomas Parkinson | .... | Ark Bridge Crew |
| Leona Naidoo | .... | Ark Bridge Crew |
| Quentin Guyon | .... | Ark Bridge Crew |
| Nicole Rudell | .... | Ark Bridge Crew |
| Chad Riley | .... | Ark Bridge Crew |
| Simon Leung | .... | Ark Bridge Crew |
| Kevin Haaland | .... | Ark Bridge Crew |
| Leigh Burrows | .... | US Army Worker |
| Tj Austin | .... | Preacher |
| Peter Arpesella | .... | Italian Prime Minister (uncredited, Stimme) |
| Chris Arreguin | .... | Doomsday Protester (uncredited) |
| Sahar Biniaz | .... | Showgirl (uncredited) |
| Anthony Bonaventura | .... | Riot Motorist (uncredited) |
| Terence Dament | .... | Bridge Crew #3 (uncredited) |
| Lea Deesing | .... | Doomsdayer (uncredited) |
| Norman Deesing | .... | Doomsdayer (uncredited) |
| Abigail Delves | .... | Little Girl (uncredited) |
| Paula Elle | .... | Woman (uncredited) |
| Eddie L. Fauria | .... | Sgt. Lourke (uncredited) |
| Gladis Giada | .... | New Age Hippie (uncredited) |
| Jacob Goodall | .... | Doomsday Man (uncredited) |
| Ashley Hand | .... | Deck 44 Passenger (uncredited) |
| Ayana Haviv | .... | Singer (singing voice) (uncredited) |
| Waléra Kanischtscheff | .... | Zultan's Trainer (uncredited, Stimme) |
| Rena Kawabata | .... | Japanese Wife (uncredited) |
| Marco Khan | .... | Preacher (uncredited) |
| Erik Kowalski | .... | Protestor (uncredited) |
| Jonathan Lane | .... | Guy in Street (uncredited) |
| Tom MacNeill | .... | Deck 44 Passenger (uncredited) |
| Robert Malina | .... | CNN Reporter (uncredited) |
| William Myers | .... | Doomsdayer (uncredited) |
| Jessica Provencher | .... | Doomsdayer (uncredited) |
| Larry Purtell | .... | Protestor (uncredited) |
| Michael Karl Richards | .... | Wil Delgado (uncredited) |
| David Richmond-Peck | .... | Political Aide (uncredited) |
| Charlie Robson | .... | Air Force One Tech (uncredited) |
| Joshua Salvati | .... | (uncredited) |
| Dan Savoie | .... | Zultan's Entourage (uncredited) |
| Richard Schimmelpfenneg | .... | Protester (uncredited) |
| Eric Shackelford | .... | Crazy Protester (uncredited) |
| Patricia Shih | .... | Violinist (uncredited) |
| Robyn Jean Springer | .... | Doomsdayer (uncredited) |
| Michael Stevens | .... | Ark Boarding Officer (uncredited) |
| Dale Tarrant | .... | Motorcycle Cop (uncredited) |
| Ian Thompson | .... | Motorcycle Cop (uncredited) |
| Derek Versteeg | .... | Scientist (uncredited) |
| Yuel Yawney | .... | Violinist (uncredited) |
| Jerome Young | .... | Tony (uncredited) |