| Keanu Reeves | .... | John Wick |
| Michael Nyqvist | .... | Viggo Tarasov |
| Alfie Allen | .... | Iosef Tarasov |
| Willem Dafoe | .... | Marcus |
| Dean Winters | .... | Avi |
| Adrianne Palicki | .... | Ms. Perkins |
| Omer Barnea | .... | Gregori |
| Toby Leonard Moore | .... | Victor |
| Daniel Bernhardt | .... | Kirill |
| Bridget Moynahan | .... | Helen |
| John Leguizamo | .... | Aurelio |
| Ian McShane | .... | Winston |
| Bridget Regan | .... | Addy |
| Lance Reddick | .... | Hotel Manager / Charon |
| Keith Jardine | .... | Kuzma |
| Tait Fletcher | .... | Nicholai |
| Kazimieras Tauginas | .... | Ivan |
| Alexander Frekey | .... | Alexander |
| Thomas Sadoski | .... | Jimmy |
| Randall Duk Kim | .... | Continental Doctor |
| David Patrick Kelly | .... | Charlie |
| Clarke Peters | .... | Harry |
| Kevin Nash | .... | Francis |
| Gameela Wright | .... | Delivery Woman |
| Vladislav Koulikov | .... | Pavel |
| Munro M. Bonnell | .... | Priest |
| Pat Squire | .... | Elderly Woman |
| Vladimir Troitsky | .... | Team Leader |
| Stefan Ackermann | .... | Red Circle Club Goer (uncredited) |
| Joseph K. Bevilacqua | .... | Man on Bus Reading the New York Times (uncredited) |
| Carolyn Blair | .... | Red Circle Club Goer (uncredited) |
| William Andrew Brewer | .... | Tattooed Security Guard (uncredited) |
| Kenneth Carrella | .... | Red Circle Security (uncredited) |
| Chris Chasey | .... | Guy in the Club (uncredited) |
| Courtney Cooper | .... | Bath House Model (uncredited) |
| Samantha Crawford | .... | Red Circle Club Goer (uncredited) |
| Johnny DiGiorgio | .... | Nephew (uncredited) |
| David Douglas | .... | Assassin (uncredited) |
| Annoula Dritsas | .... | Red Circle Club Goer (uncredited) |
| Tim Falter | .... | Assassin (uncredited) |
| Thayr Harris | .... | Red Circle Security (uncredited) |
| Nadia Kay | .... | Hot Girl (uncredited) |
| Dennis Keiffer | .... | Club Goon (uncredited) |
| Natalia Kiriya | .... | Red Circle Model (uncredited) |
| Christopher Kolling | .... | Red Circle Club Goer (uncredited) |
| Ilan Krigsfeld | .... | Bathhouse Thug (uncredited) |
| Mack Kuhr | .... | Sniper #1 (uncredited) |
| Luke Lesko | .... | Luke (uncredited) |
| Erik Martin | .... | Russian Thug (uncredited) |
| Meghan Mazurczyk | .... | Bath House Model (uncredited) |
| Yana Milanberg | .... | Nightclub Dancer (uncredited) |
| Julian Mileta | .... | Club Promoter (uncredited) |
| Roman Mitichyan | .... | Red Circle Security (uncredited) |
| Inna Muratova | .... | Girl in the Club (uncredited) |
| Karen Nazarov | .... | Red Circle Club Dancer (uncredited) |
| Joseph Oliveira | .... | Yuri (uncredited) |
| Luc Owono | .... | Nigerian Prince (uncredited) |
| Matt Parker | .... | Tenor saxophonist (uncredited) |
| Andrew Paterini | .... | Red Circle Club Goer (uncredited) |
| Charles Pendelton | .... | Doorman (uncredited) |
| Brian James Pepe | .... | Russian Bodyguard (uncredited) |
| J. J. Perry | .... | Bathroom Security (uncredited) |
| Jennifer Pientka | .... | Red Circle Club Goer (uncredited) |
| Elizabeth Saint | .... | Russian Model (uncredited) |
| Lysane Sanchez | .... | Red Circle Club Goer (uncredited) |
| Courtney Sanello | .... | Red Circle Waitress (uncredited) |
| George Schroeder | .... | Hitman (uncredited) |
| Paugh Shadow | .... | Assassin (uncredited) |
| DiFenni Shi | .... | Red Circle Club Goer (uncredited) |
| Marija Skangale | .... | Red Circle Cage Dancer (uncredited) |
| Polina Strelkova | .... | Red Circle Club Goer (uncredited) |
| Tuna Tekeli | .... | Russian Nightclub Patron (uncredited) |
| Manolo Tenes | .... | Goon (uncredited) |
| Scott Tixier | .... | Violinist (uncredited) |
| Uzimann | .... | Store Cashier (uncredited) |
| Arthur Vint | .... | Burlesque Drummer (uncredited) |
| Sam Yazbeck | .... | Red Circle Valet Driver (uncredited) |
| Zenon Zeleniuch | .... | Team Leader (uncredited) |
| Alex Ziwak | .... | Assassin (uncredited) |