| Chris Pine | .... | Jack Ryan |
| Keira Knightley | .... | Cathy Muller |
| Kevin Costner | .... | Thomas Harper |
| Kenneth Branagh | .... | Viktor Cherevin |
| Lenn Kudrjawizki | .... | Constantin |
| Alec Utgoff | .... | Aleksandr Borovsky |
| Peter Andersson | .... | Dimitri Lemkov |
| Elena Velikanova | .... | Katya |
| Nonso Anozie | .... | Embee Deng |
| Seth Ayott | .... | Teddy Hefferman |
| Colm Feore | .... | Rob Behringer |
| Gemma Chan | .... | Amy Chang |
| Aleksandar Aleksiev | .... | Cherevin's Bodyguard |
| Andrew Byron | .... | Cherevin's Bodyguard |
| Derek Lea | .... | Cherevin's Bodyguard |
| Andy Butcher | .... | Cherevin's Guest Driver |
| Lloyd Bass | .... | Harper's Driver |
| Lloyd Bass | .... | Exfil Operator |
| Marat Berdyyev | .... | Sorokin's Bodyguard |
| Leonard Redlich | .... | Sherevin's Doctor |
| Nick Court | .... | Field Doctor |
| Nathan Wiley | .... | Corpsman |
| Parker Sawyers | .... | Corpsman |
| Georg Nikoloff | .... | Van Driver (T-Bone) |
| Angus Wright | .... | Tall Man |
| Hubert Hanovich | .... | Maitre D |
| Alexander Mercury | .... | Waiter |
| Benny Maslov | .... | Cherevin's Secretary |
| Benny Maslov | .... | CIA Payoff Guard |
| Terry Cade | .... | Russian Henchman |
| Lee Morrison | .... | Russian Henchman |
| Jordi Casares | .... | Exfil Operator |
| James Grogan | .... | Exfil Operator |
| Russell Barnett | .... | Scruffy Agent |
| Mike Noble | .... | Junior Analyst |
| Montego Glover | .... | CIA Agent |
| Mike Houston | .... | CIA Agent |
| Jordan King | .... | Aide |
| Juliana Yazbeck | .... | Aide |
| Drew Marquardt | .... | Aide |
| Akihiro Lawrence Kotabe | .... | Aide |
| Richard Wheeldon | .... | Aide |
| Santino Fontana | .... | Running Banker |
| Sam Rosen | .... | Running Banker |
| Karen David | .... | FBI Lead Agent |
| Matt Rippy | .... | Agent Simmons (Dearborn) |
| Bogdan Kominowski | .... | Mr. Borovsky |
| Maggie Daniels | .... | Mrs. Borovsky |
| Erich Redman | .... | Ancient Priest |
| Amy J. Kim | .... | UN Announcer |
| Kate Arneil | .... | Distinguished Woman |
| Kieron Jecchinis | .... | Walter Reed Doctor |
| Ian Bonar | .... | Student |
| Daisy Ashford | .... | Student |
| Abi Awoyemi | .... | Student |
| Pat Kiernan | .... | Anchor |
| Annika Pergament | .... | Mary |
| Shane Steyn | .... | J & C Driver |
| Cate Myddleton-Evans | .... | Russian Maid |
| Isobel Pravda | .... | Moscow Hotel Receptionist |
| David Paymer | .... | Dixon Lewis |
| David Hayman | .... | Sergey Dostal |
| Meghann Marty | .... | UN US Interpreter |
| William Meredith | .... | Auto-Plant Guard |
| Michael Starke | .... | Auto-Plant Worker |
| Hannah Taylor Gordon | .... | Sarah |
| Mike Siegel | .... | New York DWP Worker |
| Neil Sheppeck | .... | New York DWP Worker |
| John Schwab | .... | New York DWP Worker |
| Jeff Mash | .... | New York DWP Worker |
| Frank Harts | .... | City Worker |
| Cotter Smith | .... | NY Police |
| Chinasa Ogbuagu | .... | NY Police |
| Steven Lee Merkel | .... | FBI Agent |
| Eisa Davis | .... | FBI Explosives Expert |
| Bhanu Alley | .... | Russian Office Worker (uncredited) |
| Habib Anibaba | .... | Swat Team Officer (uncredited) |
| Lee Asquith-Coe | .... | SWAT Boat Commander (uncredited) |
| Eddie Bagayawa | .... | Office Worker (uncredited) |
| Peter Bartfay | .... | Nypd Cop (uncredited) |
| Mikhail Baryshnikov | .... | The Minister Sorokin (uncredited) |
| Donald E G Bentley | .... | Marine (uncredited) |
| Paul Blackwell | .... | New York Banker (uncredited) |
| Ancuta Breaban | .... | Lady of the Night (uncredited) |
| Jill Buchanan | .... | Russian Citizen (uncredited) |
| Siong Loong Choong | .... | Banker (uncredited) |
| Joseph Cinko | .... | Porter (uncredited) |
| Chris Cowlin | .... | Banker (uncredited) |
| Richard Cullen | .... | Chauffeur (uncredited) |
| Graham Curry | .... | Jack's Platoon Friend(archive footage) (uncredited) |
| Leigh Dent | .... | Passerby (uncredited) |
| Simon DeSilva | .... | Banker (uncredited) |
| John Duggan | .... | Passerby (uncredited) |
| Robert Eames | .... | Banker (uncredited) |
| Lalaine Fabi | .... | Wall Street Businesswoman (uncredited) |
| Tim Falter | .... | NYC Tourist (uncredited) |
| James Farley | .... | Officer Farley (uncredited) |
| Dino Fazzani | .... | NYPD (uncredited) |
| Marco Flammer | .... | Wall Street Employee (uncredited) |
| Jake Francis | .... | Banker (uncredited) |
| Nichola Fynn | .... | Physio Nurse (uncredited) |
| Neve Gachev | .... | Russian Office Worker (uncredited) |
| Julian Gillard | .... | American Soldier (uncredited) |
| Jim Gunter | .... | Wall Street Employee (uncredited) |
| Lucas Hansen | .... | LSE Student 2 (uncredited) |
| Lee Nicholas Harris | .... | Wall Street Employee (uncredited) |
| Stefanie Harris | .... | Nurse (uncredited) |
| Shane Hart | .... | Russian Businessman (uncredited) |
| Felix Hiciano | .... | Pedestrian (uncredited) |
| Luke Hope | .... | Russian Banker (uncredited) |
| Lewis James | .... | Russian Witness (uncredited) |
| Celine Jedidi | .... | Restaurant Diner (uncredited) |
| Timothy Paul Jobe | .... | NYPD Officer Williams (uncredited) |
| Vaughn Johseph | .... | American President VO (uncredited) |
| Camilla Joyce | .... | Russian Citizen (uncredited) |
| Ian Kemp | .... | Maitre D (uncredited) |
| Kenneth Kopolovicz | .... | NYPD Police Officer (uncredited) |
| Keith Larkin | .... | VIP Bodyguard (uncredited) |
| Jorge Leon Martinez | .... | University Student (uncredited) |
| Olivia Quinn | .... | Office Worker (uncredited) |
| Lucinda Lewis | .... | Wall Street Broker (uncredited) |
| Lucinda Lewis | .... | NY (uncredited) |
| Price Lindsey | .... | Waiter (uncredited) |
| Elliott Mahaffey | .... | CIA Agent (uncredited) |
| Teresa Mahoney | .... | Driver (uncredited) |
| Patricia Mantuano | .... | NYPD (uncredited) |
| Stuart Matthews | .... | Vendor (uncredited) |
| Martyn Mayger | .... | Russian Citizen (uncredited) |
| Vander McLeod | .... | FBI Agent (uncredited) |
| Mike McVearry | .... | Wall Street Employee (uncredited) |
| Eric Michels | .... | FBI Operative (uncredited) |
| Morris Minelli | .... | V.I.P. (uncredited) |
| Alex Moore | .... | SWAT Officer (uncredited) |
| Stuart Mulcaster | .... | Driver (uncredited) |
| Stuart Mulcaster | .... | Office Worker (uncredited) |
| Benjayx Murphy | .... | Deluded Russian Youth (uncredited) |
| Bryan Parry | .... | Davies (uncredited) |
| Ricky Rajpal | .... | VIP Business Man (uncredited) |
| Charles Rosa | .... | NYC Businessman (uncredited) |
| Deborah Rosan | .... | Customer (uncredited) |
| Julisita Salcedo | .... | Wall Street Employee (uncredited) |
| George Schroeder | .... | Construction Worker (uncredited) |
| Santi Scinelli | .... | Tourist in the square (uncredited) |
| Ian Seale | .... | CNN News Anchor (uncredited) |
| Mark Shrimpton | .... | SWAT Team (uncredited) |
| Mark Stedman | .... | Russian Doorman (uncredited) |
| Tom Swacha | .... | Russian Choir Singer (uncredited) |
| Gerald Tomkinson | .... | New York City Banker (uncredited) |
| Claira Watson Parr | .... | Student (uncredited) |
| Lucas Antoine Starrets | .... | NYPD (uncredited) |
| Yusei | .... | CIA Agent (uncredited) |